Closing
Do statins improve all-cause mortality versus placebo?
Mostly studied in type 2 & unspecified diabetes. Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, the results disagree.
NoUnsureYes
- Belief
- 0.50 (range 0.00–0.55)
- Trials for
- 3
- Trials against
- 2
- Inconclusive
- 8
Already under way
- A Registry-based Randomized Controlled Trial of Moderate-intensity Statin Therapy vs. Individualized Low-density Lipoprotein Cholesterol Target-based Therapy…NCT07359105 · recruiting · started 2026
- Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus in Prediabetic Patients With…NCT06767774 · recruiting · started 2025
- Comparison of Low-Intensity Statin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus in Prediabetic Patients With…NCT05579626 · enrolling by invitation · started 2023
The evidence so far
- Registered trials
- 113
- With posted results
- 15
- Published papers
- 97
Of 19 decided analyses: 5 favor statins, 12 find no difference, 2 favor the comparator.
Papers
- Pravastatin and cardiovascular risk in moderate chronic kidney disease.Trial report · 2009
- [Clinical study of the month. The ALLHAT-LLT trial].Trial report · 2003
- Rosuvastatin and cardiovascular events in patients undergoing hemodialysis.Trial report · 2009
- Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial.Trial report · 2010
- The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K.Trial report · 2011
- Atorvastatin therapy may reduce the incidence of sudden cardiac death in patients with advanced chronic heart failure.Trial report · 2008
Trials
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 2 posted results
- Randomized Trial to Prevent Vascular Events in HIV - REPRIEVENCT02344290 · 4 posted results
- A Large Scale Clinical Trial Testing the Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic Congestive Heart FailureNCT00336336 · 2 posted results
- A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular UltrasoundNCT01200056
- A Randomized Comparison of Low-dose Versus High-dose Rosuvastatin on Optical Coherence Tomography Based Early Vascular Healing for Patients With Acute Coronary SyndromeNCT03007524
- Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and CancerNCT05976893
- Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus in Prediabetic Patients With Atherosclerotic Cardiovascular DiseaseNCT06767774
- PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis (PISTIAS-2): A Multicenter, Open-label, Blinded-endpoint, Randomized Controlled TrialNCT06902740