Contribute

Each model is a living review that the whole community maintains. Scientists add evidence, challenge assumptions, propose experiments, run them, or fund them. Evidence decides what is accepted, not votes.

OpenQuestion is in private preview. The process below describes how contributions are handled; public contributions open when the models are published.

Scientists and clinicians

  • Add a study or dataset to a causal link, with its study design.
  • Challenge a link or a parameter estimate.
  • Add a mechanism the model is missing.
  • Propose a new question: a phenotype, a population and the trials behind it.

Labs

  • Describe your capabilities and meet the calibration standards.
  • Run approved experiments and return data with full metadata.
  • Propose changes to protocol standards.

How labs join →

Funders and patient groups

  • Fund a specific experiment, or a milestone such as resolving a failed prediction.
  • See what each experiment is expected to change before it runs.

How a contribution is reviewed

  1. Verification

    Every citation must resolve on PubMed with a matching title, every parameter must be defined, and no trial may serve as both evidence and an out-of-sample test.

  2. Re-validation

    The model is rebuilt and every prediction re-checked against the held-out trials. A change that worsens out-of-sample performance must justify itself.

  3. Review by curators

    Structural changes (new links, mechanisms, priors) are reviewed by the model's curators. Results from qualified laboratories are incorporated directly, within minutes.

  4. Credit

    Accepted contributions are credited by name and ORCID in the version history, and each model version is citable.

Ground rules

  • Not medical advice. Models describe mechanisms and evidence, not treatment for individuals.
  • No personal health information in any model or contribution.
  • Conflicts of interest are declared on every contribution.
  • Laboratory experiments only: cell culture and invertebrates. No human trials are designed here.
  • Research that could increase the harm of a pathogen is out of scope.