Closing
Do statins improve all-cause mortality more than other treatments?
Mostly studied in coronary & atherosclerotic disease. Also asked versus placebo.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 1
Already under way
- A Registry-based Randomized Controlled Trial of Moderate-intensity Statin Therapy vs. Individualized Low-density Lipoprotein Cholesterol Target-based Therapy…NCT07359105 · recruiting · started 2026
- OPtimal Medical Strategy for Patients With Acute Coronary Syndrome Treated With Drug-eluting Stents: Enhancing Outcomes With antiPlatelet and Lipid-lowering…NCT07432516 · not yet recruiting · started 2026
- Utilizing Lipid-lowering Therapy With Moderate-intensity Statin Plus Ezetimibe in Chronic Kidney Disease Patients With Concomitant Atherosclerotic…NCT07524101 · recruiting · started 2026
- an Investigator-initiated, Multicenter, Open-label, 2-by-2 Factorial, and Randomized Trial to Evaluate the Role of Aspirin and High-intensity Statin Therapy,…NCT06676280 · recruiting · started 2025
- Comparing the Moderate Intensity STatin With Ezetimibe COmbination TheraPy With High Intensity Statin Monotherapy on Coronary PLAQUE StabilizationNCT06767345 · recruiting · started 2025
The evidence so far
- Registered trials
- 113
- With posted results
- 15
- Published papers
- 97
Of 19 decided analyses: 5 favor statins, 12 find no difference, 2 favor the comparator.
Papers
- Pravastatin and cardiovascular risk in moderate chronic kidney disease.Trial report · 2009
- [Clinical study of the month. The ALLHAT-LLT trial].Trial report · 2003
- Rosuvastatin and cardiovascular events in patients undergoing hemodialysis.Trial report · 2009
- Rosuvastatin for primary prevention in older persons with elevated C-reactive protein and low to average low-density lipoprotein cholesterol levels: exploratory analysis of a randomized trial.Trial report · 2010
- The Anglo-Scandinavian Cardiac Outcomes Trial: 11-year mortality follow-up of the lipid-lowering arm in the U.K.Trial report · 2011
- Atorvastatin therapy may reduce the incidence of sudden cardiac death in patients with advanced chronic heart failure.Trial report · 2008
Trials
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 2 posted results
- Randomized Trial to Prevent Vascular Events in HIV - REPRIEVENCT02344290 · 4 posted results
- A Large Scale Clinical Trial Testing the Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic Congestive Heart FailureNCT00336336 · 2 posted results
- A Prospective, Double-blinded, Randomised Study to Evaluate the Effects of Different Doses of Statin Treatment on Plaque Volume and Composition in Coronary Disease Determined by Virtual Histology Using Intravascular UltrasoundNCT01200056
- A Randomized Comparison of Low-dose Versus High-dose Rosuvastatin on Optical Coherence Tomography Based Early Vascular Healing for Patients With Acute Coronary SyndromeNCT03007524
- Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and CancerNCT05976893
- Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus in Prediabetic Patients With Atherosclerotic Cardiovascular DiseaseNCT06767774
- PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis (PISTIAS-2): A Multicenter, Open-label, Blinded-endpoint, Randomized Controlled TrialNCT06902740