Closing
Do supplements & botanicals improve liver & MASLD versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- An Interventional Study Investigating the Effects of Probiotics on Body Weight and Metabolic HomeostasisNCT06989177 · recruiting · started 2025
- An Intervention Study Investigating Effect of Dietary Protein Supplementation on Body Weight and Metabolic HomeostasisNCT06989203 · recruiting · started 2025
- Direct Versus Indirect Effect of Amino Acids on Hepatokines in Healthy Subjects and Patients With Non-alcoholic Fatty Liver DiseaseNCT06240039 · active not recruiting · started 2024
- Effect of the Administration of Probiotics Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Patients With Prediabetes.NCT04341571 · active not recruiting · started 2019
The evidence so far
- Registered trials
- 9
- With posted results
- 0
- Published papers
- 2
Of 1 decided analyses: 1 favor supplements & botanicals, 0 find no difference, 0 favor the comparator.
Papers
- Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial.Trial report · 2011
- Meta-Analysis of Randomized Controlled Trials of Pharmacologic Agents in Non-alcoholic Steatohepatitis.Meta-analysis / systematic review
Trials
- An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver DiseaseNCT01720719
- Efficacy and Safety of Chinese Herbal Medicine Wen Xin Granules for the Treatment of Unstable Angina Pectoris With Yang Deficiency and Blood Stasis Syndrome: Study Protocol for a Randomized Controlled TrialNCT04661709
- Clinical Evaluation of Fenugreek Seed Extract, a Nutraceutical in Patients With Type- 2 Diabetes: An Add-On StudyNCT02693392
- A Phase I/IIa Trial to Evaluate the Safety, Tolerability, PK, and Preliminary Efficacy of Single and Multiple Ascending Doses of YN001 in Healthy Subjects and Multiple Ascending Doses of YN001 in Patient With Coronary AtherosclerosisNCT06048588
- An Intervention Study Investigating Effect of Dietary Protein Supplementation on Body Weight and Metabolic HomeostasisNCT06989203
- An Interventional Study Investigating the Effects of Probiotics on Body Weight and Metabolic HomeostasisNCT06989177
- Direct Versus Indirect Effect of Amino Acids on Hepatokines in Healthy Subjects and Patients With Non-alcoholic Fatty Liver DiseaseNCT06240039
- Effect of Administration of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Patients With PrediabetesNCT03029390