Closing
Do statins improve body weight & composition versus placebo?
Mostly studied in obesity & overweight. Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 2
Already under way
- The Effects of Rosuvastatin on Physiological Adaptation and Safety During Regular Long-Distance Running Training: A Randomized Controlled TrialNCT07401017 · not yet recruiting · started 2026
- A Drug-drug Interaction Study to Evaluate the Impact of Multiple Subcutaneous Injections of ZT002 on the Pharmacokinetics of Metformin, Warfarin, Rosuvastatin…NCT07550816 · recruiting · started 2026
- AtorvaStatin Postpartum and Reduction of Cardiovascular risK (SPARK): A Randomized Placebo-controlled Trial of Atorvastatin Postpartum for Reduction of…NCT06632379 · recruiting · started 2025
- Comparing the Moderate Intensity STatin With Ezetimibe COmbination TheraPy With High Intensity Statin Monotherapy on Coronary PLAQUE StabilizationNCT06767345 · recruiting · started 2025
- Stimulation of Regional Lipolysis and Adipocyte Lipolysis ProteinsNCT06416969 · recruiting · started 2024
The evidence so far
- Registered trials
- 45
- With posted results
- 8
- Published papers
- 4
Of 5 decided analyses: 1 favor statins, 4 find no difference, 0 favor the comparator.
Papers
- No evidence of pitavastatin effect on muscle area or density among people with HIV.Trial report · 2025
- Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): a randomized trial and cohort study.Trial report · 2001
- Lifestyle factors as predictors of nonadherence to statin therapy among patients with and without cardiovascular comorbidities.Observational study · 2014
- Statins and New-Onset Diabetes Mellitus and Diabetic Complications: A Retrospective Cohort Study of US Healthy Adults.Observational study · 2015
Trials
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 2 posted results
- Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower CohortNCT02910154
- An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver DiseaseNCT01720719
- Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With DyslipidaemiaNCT06841536
- Effect of Virgin Coconut Oil (VCO) on Cardiometabolic Parameters in Patients With Dyslipidemia: A Randomized, add-on, Placebo-controlled Clinical TrialNCT03906539
- The Effects of Rosuvastatin on Physiological Adaptation and Safety During Regular Long-Distance Running Training: A Randomized Controlled TrialNCT07401017
- Comparing the Moderate Intensity STatin With Ezetimibe COmbination TheraPy With High Intensity Statin Monotherapy on Coronary PLAQUE StabilizationNCT06767345
- Short Term Effect of Fluvastatin on Brown Adipose Tissue Thermogenesis and Activity in HumansNCT03189511