Closing
Do statins improve kidney outcomes versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Unlikely. So far, the results disagree.
NoUnsureYes
- Belief
- 0.00 (range 0.00–0.55)
- Trials for
- 0
- Trials against
- 1
- Inconclusive
- 3
Already under way
- Effect of Atorvastatin and Omega 3 Combination Therapy on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes and Combined…NCT05365438 · recruiting · started 2022
The evidence so far
- Registered trials
- 61
- With posted results
- 6
- Published papers
- 19
Of 6 decided analyses: 0 favor statins, 5 find no difference, 1 favor the comparator.
Papers
- Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS).Trial report · 2009
- Cost-effectiveness of Simvastatin plus Ezetimibe for Cardiovascular Prevention in CKD: Results of the Study of Heart and Renal Protection (SHARP).Trial report · 2016
- Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase.Trial report · 2017
- Efficacy of statins in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials.Meta-analysis / systematic review · 2016
- The effect of statins on renal outcomes in patients with diabetic kidney disease: A systematic review and meta-analysis.Meta-analysis / systematic review · 2017
- Effects of atorvastatin and rosuvastatin on renal function: a meta-analysis.Meta-analysis / systematic review · 2013
Trials
- Randomized Trial to Prevent Vascular Events in HIV - REPRIEVENCT02344290 · 2 posted results
- A Prospective, Exploratory, Cohort Clinical Study Comparing the Effects of Oral Statins With or Without Folic Acid on Carotid Plaque Stability.NCT07680595
- Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With DyslipidaemiaNCT06841536
- Assessment of the Effect of Atorvastatin and N-acetyl Cysteine on Prevention of Contrast Induced Nephropathy in Patients Undergoing Coronary Angiography CINNCT06139952
- High Dose Atorvastatin Raises Threshold of Contrast Induced Nephropathy in Diabetic Patients Undergoing Elective Coronary InterventionNCT04375787
- Randomised, Double Blind, Placebo Controlled Trial of Angiotensin Converting Enzyme Inhibitors and Statins in the Prevention of Long Term Complications in Young People With Type 1 DiabetesNCT01581476
- Atorvastatin Pre-Treatment Influences the Risk of Percutaneous Coronary Intervention Study 2NCT01058057
- Heart Outcomes Prevention Evaluation-3NCT00468923