Closing
Do statins improve quality of life & behaviour versus placebo?
Mostly studied in coronary & atherosclerotic disease.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 5
Already under way
- Prospective RandomizEd Evaluation and Management of Premature aTherosclerosisNCT07232069 · recruiting · started 2026
- OPtimal Medical Strategy for Patients With Acute Coronary Syndrome Treated With Drug-eluting Stents: Enhancing Outcomes With antiPlatelet and Lipid-lowering…NCT07432516 · not yet recruiting · started 2026
- Vascular Intervention Strategies Trial for Alzheimer's (VISTA)NCT07447206 · not yet recruiting · started 2026
- Effectiveness and Safety of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia…NCT06686615 · recruiting · started 2025
- Comparing the Moderate Intensity STatin With Ezetimibe COmbination TheraPy With High Intensity Statin Monotherapy on Coronary PLAQUE StabilizationNCT06767345 · recruiting · started 2025
The evidence so far
- Registered trials
- 102
- With posted results
- 12
- Published papers
- 14
Of 8 decided analyses: 0 favor statins, 7 find no difference, 1 favor the comparator.
Papers
- The effect of a brief action planning intervention on adherence to double-blind study medication, compared to a standard trial protocol, in the Atorvastatin in Factorial with Omega EE90 Risk Reduction in Diabetes (AFORRD) clinical trial: A cluster randomised sub-study.Trial report · 2016
- Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase.Trial report · 2017
- A prospective study of pravastatin in the elderly at risk: new hope for older persons.Trial report
- Proportion and risk indicators of nonadherence to statin therapy: a meta-analysis.Meta-analysis / systematic review
- Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis.Meta-analysis / systematic review · 2014
- Systematic Review of the Effect of Adherence to Statin Treatment on Critical Cardiovascular Events and Mortality in Primary Prevention.Meta-analysis / systematic review · 2018
Trials
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 2 posted results
- Simvastatin as a Treatment for Pulmonary HypertensionNCT00180713 · 1 posted result
- Improving Equitable Acces and Adherence to Secondary Prevention Therapy With a Fixed-Dose Combination DrugNCT01321255
- Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower CohortNCT02910154
- Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and CancerNCT05976893
- Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus in Prediabetic Patients With Atherosclerotic Cardiovascular DiseaseNCT06767774
- Dapagliflozin Effect in Cognitive Impairment in Stroke TrialNCT05565976
- Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With DyslipidaemiaNCT06841536