Open
Do statins improve pharmacokinetics & dosing versus placebo?
Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Unlikely. So far, the results disagree.
NoUnsureYes
- Belief
- 0.00 (range 0.00–0.55)
- Trials for
- 0
- Trials against
- 1
- Inconclusive
- 0
Already under way
No registered trial that could settle this is recruiting or active.
The evidence so far
- Registered trials
- 130
- With posted results
- 15
- Published papers
- 8
Of 4 decided analyses: 0 favor statins, 4 find no difference, 0 favor the comparator.
Papers
- Statin Use and the Risk of Parkinson's Disease: An Updated Meta-Analysis.Meta-analysis / systematic review · 2016
- Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis.Meta-analysis / systematic review · 2017
- Confounding of the association between statins and Parkinson disease: systematic review and meta-analysis.Meta-analysis / systematic review · 2017
- Statins use and risk of dementia: A dose-response meta analysis.Meta-analysis / systematic review · 2018
- Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia.Trial report · 2009
- Normalization of daytime triglyceridemia by simvastatin in fasting normotriglyceridemic patients with premature coronary sclerosis.Trial report · 2003
Trials
- A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Administering Multiple Oral Doses of GSK1292263 Alone and With AtorvastatinNCT01218204 · 26 posted results
- An Open-Label, Definitive Bioequivalence Study to Compare the Pharmacokinetics of the Simvastatin, Nicotinic Acid, and MK0524 (Laropiprant) Components of a Formulation of MK0524B With That of Zocor™ and MK0524A TabletsNCT00943124 · 7 posted results
- Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics ProfilingNCT02437084 · 3 posted results
- Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Single Center, Randomized, Controlled Pilot Study in Healthy VolunteersNCT02286544
- A Study to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Adding ETC-1002 180 mg to Atorvastatin 80 mg Background Therapy in Statin-Treated PatientsNCT02659397
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical TrialNCT06930885
- Effects of Ezetimibe in Association With Statins on Postprandial Lipemia in Type 2 Diabetic PatientsNCT00699023
- The Need of Dosing Adjustment for Simvastatin in Obese Patients Post Bariatric Surgery- Laparoscopic Sleeve Gastrectomy (LSG)NCT03571802