Closing
Do statins improve glycemic control versus placebo?
Mostly studied in dyslipidaemia. Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, the results disagree.
NoUnsureYes
- Belief
- 0.27 (range 0.00–0.55)
- Trials for
- 1
- Trials against
- 2
- Inconclusive
- 0
Already under way
- Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers: A Randomized Phase I Clinical TrialNCT07378293 · not yet recruiting · started 2026
- OPtimal Medical Strategy for Patients With Acute Coronary Syndrome Treated With Drug-eluting Stents: Enhancing Outcomes With antiPlatelet and Lipid-lowering…NCT07432516 · not yet recruiting · started 2026
- Utilizing Lipid-lowering Therapy With Moderate-intensity Statin Plus Ezetimibe in Chronic Kidney Disease Patients With Concomitant Atherosclerotic…NCT07524101 · recruiting · started 2026
- Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CTNCT06603363 · recruiting · started 2025
- AtorvaStatin Postpartum and Reduction of Cardiovascular risK (SPARK): A Randomized Placebo-controlled Trial of Atorvastatin Postpartum for Reduction of…NCT06632379 · recruiting · started 2025
The evidence so far
- Registered trials
- 115
- With posted results
- 25
- Published papers
- 11
Of 7 decided analyses: 1 favor statins, 6 find no difference, 0 favor the comparator.
Papers
- A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients.Trial report · 2009
- Statins worsen glycemic control of T2DM in target LDL-c level and LDL-c reduction dependent manners: a meta-analysis.Meta-analysis / systematic review · 2016
- Comparative long-term efficacy and tolerability of pitavastatin 4 mg and atorvastatin 20-40 mg in patients with type 2 diabetes mellitus and combined (mixed) dyslipidaemia.Trial report · 2011
- Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients.Trial report · 2019
- Impaired endothelium-dependent skin microvascular function during high-dose atorvastatin treatment in patients with type 1 diabetes.Trial report · 2013
- The effect of HMG-CoA reductase inhibitor on insulin resistance in patients undergoing peritoneal dialysis.Trial report · 2012
Trials
- A Phase III, Randomized, Double-blind, Clinical Trial to Study the Efficacy and Safety of MK-0431D (a Fixed-dose Combination [FDC] of Sitagliptin and Simvastatin) for the Treatment of Patients With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin MonotherapyNCT01678820 · 6 posted results
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 3 posted results
- A Multicenter, Randomized, Double-Blind, Parallel Group, 12 Week Study to Evaluate the Efficacy and Safety of MK0524B Versus Atorvastatin in Patients With Mixed HyperlipidemiaNCT00289900 · 1 posted result
- An Randomized Open Label Trial on the Impact of 24 Weeks of Atorvastatin Therapy on Liver Fat Content and Abdominal Fat Content in Patients With Type 2 Diabetes Combined With High LDL-C and Non-alcoholic Fatty Liver DiseaseNCT01720719
- Comparison of Atorvastatin and Pitavastatin on the Effect of HbA1c in Acute Myocardial Infarction (AMI) Patients With Abnormal Glucose Metabolism: a Multicenter Prospective Randomized Clinical TrialNCT04945122
- Comparison of Pitavastatin Plus Ezetimibe Versus High-Intensity Statin Therapy on Risk of New-Onset Diabetes Mellitus in Prediabetic Patients With Atherosclerotic Cardiovascular DiseaseNCT06767774
- Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With DyslipidaemiaNCT06841536
- Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 in Patients With Metabolic SyndromeNCT00988364 · 2 posted results