Closing
Do statins improve costs & health-care use versus placebo?
Mostly studied in coronary & atherosclerotic disease. Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 1
Already under way
- Comparative Evaluation of Rosuvastatin and Losartan Pharmacokinetics and the Associations Between Gut Microbiota Alterations and Changes in Systemic Drug…NCT07748273 · not yet recruiting · started 2026
- AtorvaStatin Postpartum and Reduction of Cardiovascular risK (SPARK): A Randomized Placebo-controlled Trial of Atorvastatin Postpartum for Reduction of…NCT06632379 · recruiting · started 2025
- Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in RussiaNCT06858332 · recruiting · started 2025
- Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CADNCT03417388 · active not recruiting · started 2018
The evidence so far
- Registered trials
- 29
- With posted results
- 3
- Published papers
- 3
Of 4 decided analyses: 0 favor statins, 3 find no difference, 1 favor the comparator.
Papers
- Perioperative statin therapy in patients at high risk for cardiovascular morbidity undergoing surgery: a review.Meta-analysis / systematic review · 2015
- Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use.Observational study · 2013
- Sex Differences in the Use of Statins in Community Practice.Observational study · 2019
Trials
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 2 posted results
- Quality Improvement and Personalization for Statins (QUIPS) (QUE 15-286)NCT02820870 · 4 posted results
- PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.NCT05122780
- Study of Curative Effect Evaluation of DanLou Tablet on Coronary Artery Disease Not Amenable to Revascularization on the Basis of Western Medicine TherapyNCT03072082
- Study of Curative Effect Evaluation of Shexiang Baoxin Pill on Coronary Artery Disease Not Amenable to Revascularization on the Basis of Western Medicine TherapyNCT03072121
- A Multicenter, Randomized, Controlled, Double-Blind Trial to Investigate the Clinical Efficacy and Tolerability of Early Treatment With Simvastatin 40 mg Daily for 30 Days, Followed by Simvastatin 80 mg Daily Thereafter in Tirofiban-Treated Acute Coronary Syndrome Patients Who Have Been Randomized to Receive Enoxaparin or Unfractionated Heparin in Conjunction With AspirinNCT00251576
- Randomised, Double Blind, Placebo Controlled Trial of Angiotensin Converting Enzyme Inhibitors and Statins in the Prevention of Long Term Complications in Young People With Type 1 DiabetesNCT01581476
- The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy)NCT02767401