Closing
Do statins improve cardiac & vascular function versus placebo?
Mostly studied in coronary & atherosclerotic disease.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, the results disagree.
NoUnsureYes
- Belief
- 0.50 (range 0.00–0.55)
- Trials for
- 3
- Trials against
- 3
- Inconclusive
- 7
Already under way
- Prospective RandomizEd Evaluation and Management of Premature aTherosclerosisNCT07232069 · recruiting · started 2026
- A Randomized Controlled Trial of Statin Therapy Effect on Androgen Status and Erectile Function in Men With High and Very High Cardiovascular RiskNCT07460960 · recruiting · started 2026
- Effects of Bempedoic Acid/Ezetimibe/High-intensity Statin on Plaque Regression and Stabilisation of Coronary Atherosclerosis Among Patients Without…NCT07474649 · not yet recruiting · started 2026
- Clinical Study of Atorvastatin in the Treatment of Acute Kawasaki Disease Complicated With Coronary Artery Abnormalities in ChildrenNCT07530640 · recruiting · started 2026
- A Prospective, Exploratory, Cohort Clinical Study Comparing the Effects of Oral Statins With or Without Folic Acid on Carotid Plaque Stability.NCT07680595 · recruiting · started 2026
The evidence so far
- Registered trials
- 233
- With posted results
- 40
- Published papers
- 21
Of 30 decided analyses: 6 favor statins, 23 find no difference, 1 favor the comparator.
Papers
- Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study.Trial report · 2009
- Effect of rosuvastatin on progression of carotid intima-media thickness in low-risk individuals with subclinical atherosclerosis: the METEOR Trial.Trial report · 2007
- Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins.Trial report · 2016
- Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure).Trial report · 2009
- Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.Trial report · 2008
- Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure.Trial report · 2006
Trials
- Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase IINCT02347098 · 3 posted results
- Does Rosuvastatin Delay Progression of Atherosclerosis in People With HIV Infection at Moderate Cardiovascular Risk? A Multicentre Randomized, Double Blind Placebo-controlled TrialNCT01813357 · 1 posted result
- A Randomized, Double-blind, Placebo-controlled, Multicenter Parallel Group Phase 3 Study Measuring the Effect of Rosuvastatin 20 mg on Carotid Intima-Media Thickness in Chinese SubjectsNCT02546323 · 5 posted results
- A Prospective Randomized, Open-Label, Parallel-Group Comparative Study: Atorvastatin Pre-Treatment Versus Usual Care In Asian Patients With Acute Coronary Syndromes Undergoing Early Percutaneous Coronary InterventionNCT00728988 · 3 posted results
- Randomized Trial to Prevent Vascular Events in HIV - REPRIEVENCT02344290 · 2 posted results
- Simvastatin as a Treatment for Pulmonary HypertensionNCT00180713 · 3 posted results
- Role of Innate and Adaptive Immunity After Acute Myocardial Infarction BATTLE-AMI Study (B And T Types of Lymphocytes Evaluation in Acute Myocardial Infarction)NCT02428374
- Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower CohortNCT02910154