Settled
Do statins improve blood pressure versus placebo?
Mostly studied in hypertension. Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Likely. So far, repeated by independent trials.
NoUnsureYes
- Belief
- 0.80 (range 0.45–0.95)
- Trials for
- 4
- Trials against
- 1
- Inconclusive
- 4
Already under way
- Vascular Intervention Strategies Trial for Alzheimer's (VISTA)NCT07447206 · not yet recruiting · started 2026
- A Phase 1, Open-Label, Fixed-Sequence, Single-Center, Two-Period, Drug-Drug Interaction Trial in Healthy Adult Participants to Evaluate the Effect of…NCT07726368 · not yet recruiting · started 2026
- AtorvaStatin Postpartum and Reduction of Cardiovascular risK (SPARK): A Randomized Placebo-controlled Trial of Atorvastatin Postpartum for Reduction of…NCT06632379 · recruiting · started 2025
- A Multicenter, Randomized, Double-blind, Active-controlled, Parallel Group, Phase 3 Trial to Evaluate the Efficacy and Safety of Co-administrated HODO-2224-1…NCT06646354 · enrolling by invitation · started 2025
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical…NCT06930885 · recruiting · started 2025
The evidence so far
- Registered trials
- 131
- With posted results
- 18
- Published papers
- 20
Of 23 decided analyses: 5 favor statins, 15 find no difference, 3 favor the comparator.
Papers
- Impact of statin therapy on central aortic pressures and hemodynamics: principal results of the Conduit Artery Function Evaluation-Lipid-Lowering Arm (CAFE-LLA) Study.Trial report · 2009
- The effects of statins on blood pressure in normotensive or hypertensive subjects--a meta-analysis of randomized controlled trials.Trial report · 2013
- Informed shared decision-making programme for patients with type 2 diabetes in primary care: cluster randomised controlled trial.Trial report · 2018
- Association of Lipoproteins, Insulin Resistance, and Rosuvastatin With Incident Type 2 Diabetes Mellitus : Secondary Analysis of a Randomized Clinical Trial.Trial report · 2016
- Effect of pravastatin on blood pressure in people with cardiovascular disease.Trial report · 2006
- Effect of fixed dose combination treatment on adherence and risk factor control among patients at high risk of cardiovascular disease: randomised controlled trial in primary care.Trial report · 2014
Trials
- A Randomized Controlled Trial of Pravastatin to Prevent Preeclampsia in High Risk WomenNCT03944512 · 2 posted results
- Improving Equitable Acces and Adherence to Secondary Prevention Therapy With a Fixed-Dose Combination DrugNCT01321255
- Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower CohortNCT02910154
- Combined Effects of Statins and Exercise on Physiological Health Markers and Quality of Life in Patients With DyslipidaemiaNCT06841536
- Fixed Combination for Lipid and Blood Pressure Control. Randomized Cross-over StudyNCT03047538
- Action to Control Cardiovascular Risk in Diabetes (ACCORD)NCT00000620 · 2 posted results
- A Multi-center, Open-label, Randomized, 12-month, Parallel-group, Non-inferiority Study to Compare the Hemoglobin A1C Metabolism of Pitavastatin Therapy Versus Atorvastatin in Chinese Patients With Prediabetes and HypertensionNCT03532620
- Comparison of the Effects of Terlipressin and Somatostatin on Portal Pressure in Patients Undergoing Living Donor Liver TransplantationNCT07304466