Closing

Do SGLT2 inhibitors improve cardiovascular events versus placebo?

Mostly studied in type 1 diabetes. Also asked against other treatments.

Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →

Where the evidence stands

A coin flip. So far, the results disagree.

NoUnsureYes
Belief
0.50 (range 0.00–0.55)
Trials for
9
Trials against
6
Inconclusive
5

Already under way

The evidence so far

Registered trials
159
With posted results
30
Published papers
26

Of 108 decided analyses: 27 favor sglt2 inhibitors, 73 find no difference, 8 favor the comparator.

Papers

Trials

See every trial in the evidence map →