Open
Do cardiac procedures & devices improve cardiovascular events versus placebo?
Mostly studied in hypertension.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, the results disagree.
NoUnsureYes
- Belief
- 0.50 (range 0.00–0.55)
- Trials for
- 2
- Trials against
- 1
- Inconclusive
- 0
Already under way
No registered trial that could settle this is recruiting or active.
The evidence so far
- Registered trials
- 8
- With posted results
- 0
- Published papers
- 15
Of 3 decided analyses: 2 favor cardiac procedures & devices, 0 find no difference, 1 favor the comparator.
Papers
- Relative effects of statin therapy on stroke and cardiovascular events in men and women: secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Study.Trial report · 2008
- Protective effect of metformin on myocardial injury in metabolic syndrome patients following percutaneous coronary intervention.Trial report · 2014
- Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prevention: an intervention trial evaluating rosuvastatTrial report · 2009
- Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups.Meta-analysis / systematic review · 2019
- Statins for the primary prevention of cardiovascular disease.Meta-analysis / systematic review · 2011
- Statins for the primary prevention of cardiovascular disease.Meta-analysis / systematic review · 2013
Trials
- PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.NCT05122780
- The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy)NCT02767401
- A Prospective Observational Cohort Study of Predictive Factors Related to Prognosis of In-hosiptal Patients With Ischemic Stroke Due to Large-artery AtherosclerosisNCT04847752
- Effect of Statin on the Post-interventional Coronary Microcirculation DysfunctionNCT01751295
- Optimum and Stepped Care Standardised Antihypertensive Treatment With or Without Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis. ANDORRA TRIALNCT02539810
- Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total OcclusionsNCT04744571
- The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients (Age > 75 Years Old) With Coronary Artery Disease: a Randomized Controlled StudyNCT01508663
- The Success of Opening Concurrent Chronic Total Occlusion leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease (SOS-moral): Study Protocol of a Prospective Multicenter StudyNCT03372785