Settled

Do PCSK9 inhibitors improve cardiovascular events more than other treatments?

Mostly studied in coronary & atherosclerotic disease. Also asked versus placebo.

Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →

Where the evidence stands

Very likely. So far, repeated by independent trials.

NoUnsureYes
Belief
0.95 (range 0.80–1.00)
Trials for
2
Trials against
0
Inconclusive
0

Already under way

The evidence so far

Registered trials
51
With posted results
3
Published papers
37

Of 31 decided analyses: 24 favor pcsk9 inhibitors, 7 find no difference, 0 favor the comparator.

Papers

Trials

See every trial in the evidence map →