Closing

Do PCSK9 inhibitors improve cardiac & vascular function versus placebo?

Mostly studied in coronary & atherosclerotic disease.

Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →

Where the evidence stands

A coin flip. So far, the results disagree.

NoUnsureYes
Belief
0.47 (range 0.00–0.55)
Trials for
1
Trials against
1
Inconclusive
0

Already under way

The evidence so far

Registered trials
46
With posted results
6
Published papers
1

Of 4 decided analyses: 2 favor pcsk9 inhibitors, 1 find no difference, 1 favor the comparator.

Papers

Trials

See every trial in the evidence map →