Closing
Do other lipid agents improve pharmacokinetics & dosing versus placebo?
Mostly studied in dyslipidaemia.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Effectiveness and Safety of Bempedoic Acid in Combination With Ezetimibe and Either Rosuvastatin or Atorvastatin in Patients With Primary Hypercholesterolemia…NCT06686615 · recruiting · started 2025
- A Clinical Study to Evaluate the Safety and Pharmacokinetic Interaction Between HODO-22251 and HODO-22252 in Healthy AdultsNCT06578676 · recruiting · started 2024
- NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury (NACAM) TrialNCT04750616 · recruiting · started 2021
The evidence so far
- Registered trials
- 28
- With posted results
- 7
- Published papers
- 2
Of 2 decided analyses: 2 favor other lipid agents, 0 find no difference, 0 favor the comparator.
Papers
- Effect of ezetimibe on plasma adipokines: a systematic review and meta-analysis.Meta-analysis / systematic review · 2017
- Effects of ezetimibe and simvastatin on apolipoprotein B metabolism in males with mixed hyperlipidemia.Trial report · 2009
Trials
- Regulation of Cholesterol Absorption: LDL Cholesterol Response to a Combination of Phytosterols and Ezetimibe (Phyto-3)NCT00863265 · 3 posted results
- ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cARTNCT01683656
- A Study to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Adding ETC-1002 180 mg to Atorvastatin 80 mg Background Therapy in Statin-Treated PatientsNCT02659397
- Effects of Ezetimibe in Association With Statins on Postprandial Lipemia in Type 2 Diabetic PatientsNCT00699023
- A Pilot Study to Measure Plasma and Urinary Prostaglandin D2 Metabolites Evoked by NiacinNCT01275300 · 1 posted result
- A Randomized, Prospective, Open Label, Active Control, Phase IV Study to Evaluate the Effects of Statin Monotherapy or Statin / Ezetimibe Combination Therapy on Hepatic Steatosis in Patients With Hyperlipidemia and Nonalcoholic Fatty Liver DiseaseNCT03434613
- Effect of Diabetes Mellitus on Cholesterol Absorption, Synthesis and Statin EfficacyNCT00879710 · 1 posted result
- SCH 058235: Assessment of a Multiple-Dose Drug Interaction Between Ezetimibe and Rosuvastatin in Healthy Hypercholesterolemic SubjectsNCT00651144