Closing
Do other lipid agents improve glycemic control versus placebo?
Mostly studied in dyslipidaemia.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, the results disagree.
NoUnsureYes
- Belief
- 0.40 (range 0.00–0.55)
- Trials for
- 1
- Trials against
- 1
- Inconclusive
- 2
Already under way
- Utilizing Lipid-lowering Therapy With Moderate-intensity Statin Plus Ezetimibe in Chronic Kidney Disease Patients With Concomitant Atherosclerotic…NCT07524101 · recruiting · started 2026
- Repositioning Omega-3 Fatty Acids For Treatment Of Glycaemia And Cardiometabolic DiseaseNCT07677995 · enrolling by invitation · started 2026
- Dietary Fish Oil and Metformin Intervention for Heart Health in PCOSNCT06424860 · recruiting · started 2025
- A Prospective, Non-Intervention, Multi-Center Observational Study to Evaluate the Efficacy and Safety of CREZET Tablet in Patients With DyslipidemiaNCT05889143 · active not recruiting · started 2023
- Effect of Atorvastatin and Omega 3 Combination Therapy on Carotid Atherosclerosis Estimated by 3D Ultrasound in Patients With Type 2 Diabetes and Combined…NCT05365438 · recruiting · started 2022
The evidence so far
- Registered trials
- 47
- With posted results
- 12
- Published papers
- 4
Of 9 decided analyses: 1 favor other lipid agents, 7 find no difference, 1 favor the comparator.
Papers
- Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester): Effects Upon High-Sensitivity C-Reactive Protein and Lipid Parameters in Patients With Metabolic Syndrome.Trial report · 2015
- Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial.Trial report · 2024
- A randomized, double-blind, placebo-controlled study of the effect of ezetimibe on glucose metabolism in subjects with type 2 diabetes mellitus and hypercholesterolemia.Trial report · 2015
- Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials.Meta-analysis / systematic review · 2015
Trials
- A Randomized Study to Evaluate the Efficacy and Safety of Bempedoic Acid 180 + Ezetimibe 10 Fixed-Dose Combination Compared to Ezetimibe and Placebo In Subjects With T2DM and Elevated LDL-CholesterolNCT03531905 · 11 posted results
- Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients: a Randomized Crossover TrialNCT06381947
- Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 in Patients With Metabolic SyndromeNCT00988364 · 2 posted results
- Comparison of the Efficacy and AtorVastatin 20mg mOnotherapy Versus Combination Atorvastatin/Fenofibric Acid 10/135mg in the Mixed hyperlipiDemia Who Were Not at Lipid gOals With Atorvastatin 10mg Monotherapy.NCT01974297
- A Novel Preoperative Conditioning Therapy in Giant Obese Patients With the Combination of Liraglutide and a Leucine-Based Amino-Acid Infusion and Caloric RestrictionNCT02616003
- Confirmatory Study of the Efficacy and Safety of the Fixed-dose Combination Atorvastatin / Fenofibrate Versus Atorvastatin on the Lipid Profile of Patients With Type 2 Diabetes (T2D) and Dyslipidaemia (DLP).NCT04882293
- Diet/Exercise, Niacin, Fenofibrate for HIV LipodystrophyNCT00246376 · 1 posted result
- Nephropathy in Type 2 Diabetes: Effects of an Intensive Multifactorial Intervention Trial on Cardio-renal Events.NCT00535925 · 1 posted result