Closing
Does metformin improve kidney outcomes versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 1
Already under way
- Efficacy of Metformin With Antidepressant Medication as Adjunct Therapy in Depression-obesity Ccomorbidity and Ssociation With NEGR1/RPL31P12 Variants Based on…NCT07654179 · recruiting · started 2026
- Effects of 14-Day Metformin Withdrawal on OGTT-Derived Insulin Sensitivity in Adults With Metabolic Syndrome: A Randomized Controlled TrialNCT07659444 · recruiting · started 2026
- Study on the Effect of Metformin in Improving Cardiac Function After Implantation of Left Ventricular Assist DevicesNCT07666698 · not yet recruiting · started 2026
- Open-label, Double-arm, Controlled, Randomized, Multicentre Clinical Trial to Evaluate the Impact of Pharmacogenetic-guided Treatment in Patients With…NCT06851962 · active not recruiting · started 2025
- Efficacy and Safety of Henagliflozin Proline and Metformin Hydrochloride Extended-release Tablets (Ⅰ) Versus Metformin Tablets in Patients With New-onset Type…NCT06888050 · recruiting · started 2025
The evidence so far
- Registered trials
- 98
- With posted results
- 20
- Published papers
- 7
Of 1 decided analyses: 0 favor metformin, 1 find no difference, 0 favor the comparator.
Papers
- Effect of Metformin on Renal Function After Primary Percutaneous Coronary Intervention in Patients Without Diabetes Presenting with ST-elevation Myocardial Infarction: Data from the GIPS-III Trial.Trial report · 2015
- Metformin for preventing the progression of chronic kidney disease.Meta-analysis / systematic review · 2024
- Determinants of Small for Gestational Age in Women With Type 2 Diabetes in Pregnancy: Who Should Receive Metformin?Trial report · 2022
- Renal Protective Effect of Metformin in Type 2 Diabetes Patients.Observational study · 2025
- The impact of metformin on kidney disease progression and mortality in diabetic patients using SGLT2 inhibitors: a real-world cohort study.Observational study · 2025
- Risk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study.Observational study · 2017
Trials
- A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 DiabetesNCT01881828
- Adaptive Study for Efficacy and Safety of Metformin Glycinate for the Treatment of Patients With MS and DM2, Hospitalized With Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2. Randomized, Double-Blind, Phase IIIb.NCT04626089
- Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population: Implication on Diabetes Complication Risk?NCT02879409
- Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and InfertilityNCT05952882
- Effect of Farxiga on Renal Function and Size in Type 2 Diabetic Patients With HyperfiltrationNCT02911792 · 1 posted result
- Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens: a Multicentre Randomized Parallel-group Clinical TrialNCT02587741
- Metformin Continuation Safety in Diabetic Patients Undergoing Coronary AngiographyNCT04766008
- A Long Term, Open Label, Randomised Study in Patients With Type 2 Diabetes, Comparing the Combination of Rosiglitazone and Either Metformin or Sulfonylurea With Metformin Plus Sulfonylurea on Cardiovascular Endpoints and GlycaemiaNCT00379769 · 1 posted result