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Does metformin improve quality of life & behaviour versus placebo?
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Unlikely. So far, the results disagree.
NoUnsureYes
- Belief
- 0.00 (range 0.00–0.55)
- Trials for
- 0
- Trials against
- 1
- Inconclusive
- 1
Already under way
No registered trial that could settle this is recruiting or active.
The evidence so far
- Registered trials
- 153
- With posted results
- 32
- Published papers
- 4
Of 2 decided analyses: 0 favor metformin, 2 find no difference, 0 favor the comparator.
Papers
- Metformin therapy and cognitive dysfunction in patients with type 2 diabetes: A meta-analysis and systematic review.Meta-analysis / systematic review · 2020
- Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis.Meta-analysis / systematic review · 2018
- Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis.Meta-analysis / systematic review · 2025
- Repaglinide versus metformin in combination with bedtime NPH insulin in patients with type 2 diabetes established on insulin/metformin combination therapy.Trial report · 2002
Trials
- Metformin Effect on Brain Function in Insulin Resistant Elderly PeopleNCT03733132 · 1 posted result
- Metformin and Muscle in Insulin-resistant Older VeteransNCT01804049 · 1 posted result
- A Randomized Phase 3 Trial of Metformin in Patients Initiating Androgen Deprivation Therapy as Prevention and Intervention of Metabolic Syndrome: The Prime StudyNCT03031821
- Gut-Brain-axis: Targets for Improvement of Cognition in the ElderlyNCT04841668
- Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot StudyNCT03848533
- A Prospective, Randomized, Parallel-group, Adaptive Design Phase IIb/III, Multicenter Study, to Assess the Efficacy of Polychemotherapy for Inducing Remission of Newly Diagnosed Type 2 Diabetes.NCT04271189
- Does Glycated Hemoglobin Variability in Type 2 Diabetes Differ Depending on the Diabetes Treatment Threshold Used in the Qatari Population: Implication on Diabetes Complication Risk?NCT02879409
- Effectiveness Study of a Lifestyle Intervention Versus Metformin in Mothers With Recent Gestational DiabetesNCT06948825