Closing

Does metformin improve inflammation & biomarkers versus placebo?

Mostly studied in type 2 & unspecified diabetes. Also asked against other treatments.

Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →

Where the evidence stands

A coin flip. So far, one result, not yet repeated.

NoUnsureYes
Belief
0.50 (range 0.25–0.70)
Trials for
1
Trials against
0
Inconclusive
3

Already under way

The evidence so far

Registered trials
190
With posted results
37
Published papers
14

Of 21 decided analyses: 1 favor metformin, 18 find no difference, 2 favor the comparator.

Papers

Trials

See every trial in the evidence map →