Open
Does metformin cause more hypoglycaemia versus placebo?
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 2
Already under way
No registered trial that could settle this is recruiting or active.
The evidence so far
- Registered trials
- 217
- With posted results
- 106
- Published papers
- 8
Of 3 decided analyses: 0 favor metformin, 3 find no difference, 0 favor the comparator.
Papers
- Efficacy and safety of dulaglutide in patients with type 2 diabetes: a meta-analysis and systematic review.Meta-analysis / systematic review · 2016
- The effects of sulfonylureas plus metformin on lipids, blood pressure, and adverse events in type 2 diabetes: a meta-analysis of randomized controlled trials.Meta-analysis / systematic review · 2013
- Comparison of Clinical Outcomes and Adverse Events Associated With Glucose-Lowering Drugs in Patients With Type 2 Diabetes: A Meta-analysis.Meta-analysis / systematic review · 2016
- Comparison of antidiabetic drugs added to sulfonylurea monotherapy in patients with type 2 diabetes mellitus: A network meta-analysis.Meta-analysis / systematic review · 2018
- Sodium-Glucose Co-Transporter 2 Inhibitors Compared with Sulfonylureas in Patients with Type 2 Diabetes Inadequately Controlled on Metformin: A Meta-Analysis of Randomized Controlled Trials.Meta-analysis / systematic review · 2019
- An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.Trial report · 2006
Trials
- Glycemic Control in Children and Adolescents With Double Diabetes: Trial of Optimized Insulin-Metformin RegimenNCT01334125 · 2 posted results
- A Randomised Placebo Controlled Trial of the Effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE)NCT02980276 · 1 posted result
- Gut-Brain-axis: Targets for Improvement of Cognition in the ElderlyNCT04841668
- A Randomized Trial of Metformin as Adjunct Therapy for Overweight Adolescents With Type 1 DiabetesNCT01881828
- FLAT-SUGAR: FLuctuATion Reduction With inSULin and Glp-1 Added togetheRNCT01524705 · 1 posted result
- A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes MellitusNCT05343767
- Variability of Glucose Assessed in a Randomized Trial Comparing the Initiation of A Treatment Approach With Biosimilar Basal Insulin Analog Or a Titratable iGlarLixi combinatioN in Type 2 Diabetes Among South Asian Subjects (VARIATION 2 SA Trial)NCT03819790
- Liraglutide Effect and Action in Diabetes (LEAD-2): Effect on Glycaemic Control After Once Daily Administration of Liraglutide in Combination With Metformin Versus Metformin Monotherapy Versus Metformin and Glimepiride Combination Therapy in Subjects With Type 2 DiabetesNCT00318461 · 2 posted results