Closing
Does metformin improve cardiac & vascular function versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, the results disagree.
NoUnsureYes
- Belief
- 0.24 (range 0.00–0.55)
- Trials for
- 1
- Trials against
- 3
- Inconclusive
- 1
Already under way
- Focusing on the Menopausal Transition to Improve Mid-Life Women's HealthNCT06975111 · recruiting · started 2026
- Study on the Effect of Metformin in Improving Cardiac Function After Implantation of Left Ventricular Assist DevicesNCT07666698 · not yet recruiting · started 2026
- The Effect of Empagliflozin and Metformin on Oxidative Capacity and Microvascular Reactivity of Skeletal Muscle in Patients With Type 2 Diabetes MellitusNCT07771010 · recruiting · started 2026
- Dietary Fish Oil and Metformin Intervention for Heart Health in PCOSNCT06424860 · recruiting · started 2025
- Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal Hypertension - A Randomized Placebo-controlled StudyNCT06687265 · recruiting · started 2025
The evidence so far
- Registered trials
- 98
- With posted results
- 22
- Published papers
- 3
Of 14 decided analyses: 2 favor metformin, 10 find no difference, 2 favor the comparator.
Papers
- Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial.Trial report · 2010
- Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial.Trial report · 2017
- Cardiovascular safety of metformin and sulfonylureas in patients with different cardiac risk profiles.Observational study · 2016
Trials
- Cardiometabolic Disease and Pulmonary HypertensionNCT03349775 · 2 posted results
- Metformin in Insulin Resistant LV Dysfunction, a Double-blind, Placebo-controlled Trial (TAYSIDE Trial)NCT00473876 · 2 posted results
- Effect of Metformin on Insulin Sensitivity and Pan-Arterial Vascular Function in Adults With Metabolic SyndromeNCT02633488 · 1 posted result
- Exercise Dose and Metformin for Vascular Health in Adults With Metabolic SyndromeNCT03355469 · 12 posted results
- A Randomised Placebo-controlled Trial of Metformin on Progression of Carotid Atherosclerosis in Non-diabetic Patients With Cardiovascular Disease Treated With Conventional Risk Reducing AgentsNCT00723307 · 1 posted result
- Adaptive Study for Efficacy and Safety of Metformin Glycinate for the Treatment of Patients With MS and DM2, Hospitalized With Severe Acute Respiratory Syndrome Secondary to SARS-CoV-2. Randomized, Double-Blind, Phase IIIb.NCT04626089
- Focusing on the Menopausal Transition to Improve Mid-Life Women's HealthNCT06975111
- The Effect of Liraglutide Compared to Sitagliptin, Both in Combination With Metformin in Subjects With Type 2 Diabetes. A 26-week, Randomised, Open-label, Active Comparator, Three-armed, Parallel-group, Multi-centre, Multinational Trial With a 52-week ExtensionNCT00700817 · 1 posted result