Closing
Do diet, exercise & lifestyle improve cardiovascular events more than other treatments?
Mostly studied in type 2 & unspecified diabetes. Also asked versus placebo.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Patients With Obese and HFpEF: A Randomized Controlled TrialNCT07630454 · not yet recruiting · started 2026
- Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients: A Multicenter, Randomized, Open-Label TrialNCT07715929 · not yet recruiting · started 2026
- A Randomized, Open-label, Clinical Trial Evaluating the Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease…NCT07254572 · recruiting · started 2025
- Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart FailureNCT06423599 · recruiting · started 2024
- Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CADNCT03417388 · active not recruiting · started 2018
The evidence so far
- Registered trials
- 21
- With posted results
- 4
- Published papers
- 3
Of 8 decided analyses: 8 favor diet, exercise & lifestyle, 0 find no difference, 0 favor the comparator.
Papers
- Fasting substrates predict chronic kidney disease progression in CREDENCE trial patients with type 2 diabetes.Trial report · 2024
- Reduced coronary events in simvastatin-treated patients with coronary heart disease and diabetes or impaired fasting glucose levels: subgroup analyses in the Scandinavian Simvastatin Survival Study.Trial report
- Identifying optimal primary prevention interventions for major cardiovascular disease events and all-cause mortality: a systematic review and hierarchical network meta-analysis of RCTs.Meta-analysis / systematic review · 2025
Trials
- Diabetes Prevention Program Outcomes StudyNCT00038727 · 3 posted results
- Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese(MEGA Study)NCT00211705
- Does Glucagon-like Polypeptide 1 Improve Vascular Function and Inflammation?NCT01740921
- Effect and Safety of Liraglutide 3.0 mg as an Adjunct to Intensive Behaviour Therapy for Obesity in a Non-specialist SettingNCT02963935 · 1 posted result
- A Randomized, Open-label, Clinical Trial Evaluating the Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetesNCT07254572
- Coronary Artery Disease Progression by iMap Intravascular Ultrasound Analysis in Patients With PrediabetesNCT02744976
- Effect of the Low PROtein Diet on Top of DAPAgliflozin and RAASi on the Progression of Chronic Kidney Disease in Patients With Type 2 Diabetes MellitusNCT06281899
- Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients: A Multicenter, Randomized, Open-Label TrialNCT07715929