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Does insulin improve pregnancy & neonatal more than other treatments?
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
No claim has formed for this comparison yet. The trials below are registered, but none decides it.
Already under way
No registered trial that could settle this is recruiting or active.
The evidence so far
- Registered trials
- 17
- With posted results
- 4
- Published papers
- 4
Papers
- The efficacy and safety of metformin alone or as an add-on therapy to insulin in pregnancy with GDM or T2DM: A systematic review and meta-analysis of 21 randomized controlled trials.Meta-analysis / systematic review · 2022
- Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis.Meta-analysis / systematic review · 2018
- Metformin should be considered in the treatment of gestational diabetes: a prospective randomised study.Trial report · 2011
- Metformin Use in the First Trimester of Pregnancy and Risk for Nonlive Birth and Congenital Malformations: Emulating a Target Trial Using Real-World Data.Observational study · 2024
Trials
- Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy on Glycemic Control, Fetal and Neonatal Outcomes ,Randomized Controlled TrialNCT05479214
- Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.NCT01998113
- DECIDE: A Comparative Effectiveness Trial of Oral Metformin Versus Injectable Insulin for the Treatment of Gestational DiabetesNCT06445946
- Comparison of Insulin Alone to Insulin With Metformin to Treat Gestational Diabetes MellitusNCT03651531
- A Comparison of Glucovance (Glyburide and Metformin) to Insulin Therapy for the Treatment of Gestational Diabetes and Adult Onset Diabetes in PregnancyNCT00371306
- Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes Mellitus and Improving Neonatal Outcome Regarding Birth WeightNCT03106870 · 2 posted results
- Comparison of Metformin and Insulin for Management of Gestational Diabetes MellitusNCT03320694
- Continuous Glucose Monitoring Among Individuals With Gestational Diabetes Treated With Metformin Versus Insulin: Protocol for a Nested Prospective Cohort in the DECIDE RCT (DECIDE CGM)NCT06490874