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Does insulin improve all-cause mortality more than other treatments?
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
No claim has formed for this comparison yet. The trials below are registered, but none decides it.
Already under way
No registered trial that could settle this is recruiting or active.
The evidence so far
- Registered trials
- 10
- With posted results
- 2
- Published papers
- 8
Papers
- Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.Meta-analysis / systematic review · 2017
- The Association Between Antidiabetic Agents and Clinical Outcomes of COVID-19 Patients With Diabetes: A Bayesian Network Meta-Analysis.Meta-analysis / systematic review · 2022
- Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses.Meta-analysis / systematic review · 2012
- Intensive insulin therapy, insulin sensitisers and insulin secretagogues for burns: A systematic review of effectiveness and safety.Meta-analysis / systematic review · 2018
- Association of hypoglycemic treatment regimens with cardiovascular outcomes in overweight and obese subjects with type 2 diabetes: a substudy of the SCOUT trial.Trial report · 2013
- Glycaemic control and mortality in older people with type 2 diabetes: The Fremantle Diabetes Study Phase II.Trial report · 2018
Trials
- Real-world Evaluation of GLP-1 Receptor Agonists (GLP-1RA) on Efficacy and Persistence, Adherence and Therapeutic Inertia Among Type 2 Diabetes Adults With Obesity in the Department of Health of Valencia Clínico-MalvarrosaNCT05535322
- Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.NCT01998113
- Administration of Metformin and Insulin to Pancreatic Cancer Related Diabetes Mellitus (Type 3c)NCT05306028
- DECIDE: A Comparative Effectiveness Trial of Oral Metformin Versus Injectable Insulin for the Treatment of Gestational DiabetesNCT06445946
- A 12-week, Multi-center, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Assess the Efficacy and Safety of Equa (Vildagliptin) 50 mg Bid as an add-on Therapy to Insulin, With or Without Metformin, in Patients With Type 2 Diabetes MellitusNCT02002221 · 1 posted result
- Cardiovascular Outcomes in Patients With Type 2 Diabetes MellitusNCT03249506
- Comparison of Metformin and Insulin for Management of Gestational Diabetes MellitusNCT03320694
- Effect of Adding Metformin to Insulin Therapy in Pregnant Women With Type I Diabetes as Regards Pregnancy OutcomeNCT03928340