Closing
Does insulin improve blood pressure versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.35 (range 0.10–0.55)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- DECIDE: A Comparative Effectiveness Trial of Oral Metformin Versus Injectable Insulin for the Treatment of Gestational DiabetesNCT06445946 · recruiting · started 2024
- Efficacy and Safety of Liraglutide-bolus (Liraglutide Plus Prandial Insulin) Versus Glargine-bolus Therapy in Overweight / Obese Patients With Uncontrolled…NCT03087032 · recruiting · started 2019
- Triple Therapy for Type 1 Diabetes With Insulin, Semaglutide, and DapagliflozinNCT03899402 · active not recruiting · started 2019
The evidence so far
- Registered trials
- 46
- With posted results
- 29
- Published papers
- 2
Papers
- Tirzepatide outcompetes long-acting insulin in managing type 2 diabetes: a meta-analysis of three phase 3 randomized controlled trials.Meta-analysis / systematic review · 2024
- IDeglira vs insulin degludec for type 2 diabetes: a systematic review and meta-analysis.Meta-analysis / systematic review · 2025
Trials
- Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as Add on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 DiabetesNCT02128932 · 2 posted results
- Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.NCT01998113
- A Phase III, Randomized, Parallel, Double-blind, and Non-inferiority Clinical Trial to Compare Efficacy and Safety of CinnaGen-liraglutide to Innovator Liraglutide Product (Victoza®) in Patients With Type II Diabetes (T2D)NCT03421119
- A 16 Week Randomised, Open Labelled, 3 Armed, Parallel Group, Treat-to-target Trial Comparing Once Daily Injection of SIAC 30 (B), SIAC 45 (B) and Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes Failing on OAD TreatmentNCT00614055 · 2 posted results
- DECIDE: A Comparative Effectiveness Trial of Oral Metformin Versus Injectable Insulin for the Treatment of Gestational DiabetesNCT06445946
- Is the Stepping-down Approach a Better Option Than Multiple Daily Injections in Patients With Chronic Poorly-controlled Diabetes on Advanced Insulin Therapy?NCT02846233 · 1 posted result
- The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 Diabetes. A 26 Week, Randomised, Open-label, Parallel-group, Multicentre, Multinational Trial With a 26 Week ExtensionNCT00856986 · 2 posted results
- A 16 Week Randomised, Open Labelled, 3-armed, Parallel Group, Treat-to-target Trial Comparing Twice Daily (BID) Injections of SIAC 30 (B), SIAC 45 (B) and NovoMix®30, All in Combination With Metformin in Subjects With Type 2 Diabetes Failing on OAD TreatmentNCT00613951 · 2 posted results