Closing
Do GLP-1 receptor agonists improve costs & health-care use versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- SHAPE-ENDO (Strategic Hormonal Approach & Prehabilitation in Endometrial Cancer): An Open-Label, Pilot Randomized Clinical Trial Comparing Standard Immediate…NCT07462663 · not yet recruiting · started 2027
- Waiting on Atrial Fibrillation Intervention Therapy (WAIT) StudyNCT07275697 · recruiting · started 2026
- Estimating the Impact of Obesity Medications on Clinical and Economic OutcomesNCT07640139 · enrolling by invitation · started 2026
- Liraglutide Treatment in Obese Infertile PCOS WomenNCT06742710 · recruiting · started 2025
- SIGNAL - Body Fluid Proteome SIGnatures for persoNALised Intervention to Prevent Cardiovascular and Renal Complications in DiabetesNCT06954090 · enrolling by invitation · started 2025
The evidence so far
- Registered trials
- 27
- With posted results
- 7
- Published papers
- 1
Of 10 decided analyses: 4 favor glp-1 receptor agonists, 6 find no difference, 0 favor the comparator.
Papers
- Impact of semaglutide 2.4 mg on healthcare resource utilization and medical costs in patients with atherosclerotic cardiovascular disease in the United States (SHINE-ASCVD).Observational study · 2025
Trials
- A 6-WEEK, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, TWO-ARM, PARALLEL METHODOLOGY STUDY TO ASSESS THE EFFECT OF LIRAGLUTIDE ON FOOD INTAKE IN OBESE SUBJECTSNCT03041792 · 18 posted results
- SHAPE-ENDO (Strategic Hormonal Approach & Prehabilitation in Endometrial Cancer): An Open-Label, Pilot Randomized Clinical Trial Comparing Standard Immediate Surgery Versus a Multimodal Metabolic Optimization and Prehabilitation Strategy Before Surgery in Patients With Atypical Endometrial Hyperplasia or Low-Risk Endometrioid Endometrial Cancer and BMI ≥40 kg/m²NCT07462663
- Effect of Semaglutide on the Inflammatory Response and Clinical Course of Psoriatic Lesions in Patients With Type 2 Diabetes MellitusNCT06475586
- A Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Type 2 Diabetes MellitusNCT02501161 · 1 posted result
- Liraglutide or Insulin in Real Life Usage in Patients With Diabetes Mellitus Type 2NCT01484262
- A Phase 2/3, Placebo-Controlled, Efficacy and Safety Study of Once-Weekly, Subcutaneous LY2189265 Compared to Sitagliptin in Patients With Type 2 Diabetes Mellitus on MetforminNCT00734474 · 1 posted result
- A Randomized Controlled Trial Comparing the Safety and Efficacy of Liraglutide Versus Glargine Insulin for the Management of Patients With Type 2 Diabetes After Hospital DischargeNCT01919489 · 1 posted result
- A Randomized, Double Blind, Two-period Cross-over Trial Investigating the Effect of Liraglutide as Add on to Intensive Insulin Treatment on the Endogenous Glucose Production in Subjects With C-peptide Positive Type 1 Diabetes MellitusNCT02408705