Closing
Do GIP/GLP-1 & amylin agonists improve all-cause mortality versus placebo?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.35 (range 0.10–0.55)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 1
Already under way
- Tirzepatide to Reduce Recurrence and Burden After Catheter Ablation of Atrial Fibrillation: A Prospective Randomized TrialNCT07382024 · not yet recruiting · started 2026
- Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Patients With Obese and HFpEF: A Randomized Controlled TrialNCT07630454 · not yet recruiting · started 2026
- Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients: A Multicenter, Randomized, Open-Label TrialNCT07715929 · not yet recruiting · started 2026
- Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection FractionNCT06980623 · active not recruiting · started 2025
- The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in…NCT05669755 · active not recruiting · started 2023
The evidence so far
- Registered trials
- 15
- With posted results
- 2
- Published papers
- 5
Of 3 decided analyses: 1 favor gip/glp-1 & amylin agonists, 2 find no difference, 0 favor the comparator.
Papers
- [SURPASS CVOT : cardiovascular benefits with tirzepatide versus dulaglutide in type 2 diabetes].Trial report · 2026
- Cardiovascular Outcomes in Adults With Type 2 Diabetes Treated With Tirzepatide: A Systematic Review and Meta-Analysis of Real-World Studies.Meta-analysis / systematic review · 2026
- Comparative efficacy of tirzepatide and glucagon-like peptide-1 receptor agonists on cardiovascular outcomes in patients with type 2 diabetes: a systematic review and network meta-analysis.Meta-analysis / systematic review · 2026
- Tirzepatide for adults living with obesity.Meta-analysis / systematic review · 2025
- Comparative real-world outcomes of tirzepatide vs semaglutide in patients with obesity and type2 diabetes: A retrospective propensity-matched cohort study.Observational study
Trials
- A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Comparing the Efficacy and Safety of Tirzepatide Versus Placebo in Patients With Heart Failure With Preserved Ejection Fraction and Obesity (SUMMIT)NCT04847557 · 2 posted results
- A Phase 3, Randomized, Double-blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults With ObesityNCT05556512
- Comparative Effectiveness of Dulaglutide, Semaglutide, and Tirzepatide in Preventing Cardiovascular Events in Patients With Type 2 Diabetes and Obesity With or Without Atherosclerotic Cardiovascular Disease.NCT07417618
- Comparative Effectiveness of Tirzepatide and Semaglutide in Individuals at Cardiovascular RiskNCT07096063
- Comparative Effectiveness of Tirzepatide and Semaglutide in Patients at Cardiovascular Risk With Overweight or Obesity But Without DiabetesNCT07619508
- Comparative Effectiveness of Tirzepatide Versus Semaglutide in Individuals With Heart Failure With Preserved Ejection FractionNCT06914141
- Comparative Effectiveness of Tirzepatide Versus Sitagliptin in Individuals at Cardiovascular Risk (TIRZSITA-CVOT)NCT07203677
- Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection FractionNCT06980623