Settled
Do GIP/GLP-1 & amylin agonists improve inflammation & biomarkers versus placebo?
Mostly studied in obesity & overweight.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Very likely. So far, repeated by independent trials.
NoUnsureYes
- Belief
- 0.99 (range 0.84–1.00)
- Trials for
- 2
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes: a Phase 2 Double Blinded Placebo Controlled Clinical Trial (TIRTLE2)NCT06820281 · recruiting · started 2026
- A Pre-Operative Window Study of Tirzepatide in Obesity-Driven Endometrial CancerNCT07065552 · recruiting · started 2026
- Male Fertility Preservation: Efficacy Evaluation of GLP-1Receptor Agonist Therapy for Infertility in Obese Males - A Multicenter Clinical Randomized Controlled…NCT07179120 · not yet recruiting · started 2026
- The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity: A Pilot StudyNCT07218445 · recruiting · started 2026
- Efficacy, Safety and Pharmacokinetics of Cagrilintide s.c. 2.4 mg as Monotherapy and in Combination With Semaglutide s.c. 2.4 mg (CagriSema) Once Weekly for…NCT07253285 · recruiting · started 2026
The evidence so far
- Registered trials
- 58
- With posted results
- 2
- Published papers
- 0
Of 3 decided analyses: 3 favor gip/glp-1 & amylin agonists, 0 find no difference, 0 favor the comparator.
Trials
- A Master Protocol to Investigate the Efficacy and Safety of Tirzepatide Once Weekly in Participants Who Have Obstructive Sleep Apnea and Obesity: A Randomized, Double-Blind, Placebo-Controlled TrialNCT05412004 · 2 posted results
- A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Comparing the Efficacy and Safety of Tirzepatide Versus Placebo in Patients With Heart Failure With Preserved Ejection Fraction and Obesity (SUMMIT)NCT04847557 · 1 posted result
- The Effects of Tirzepatide on Coronary Plaque Lipid Content and Myocardial Microvascular Function in Overweight and Obese People With Coronary Disease - The IDEAL-COR StudyNCT06606821
- Fully Closed-Loop Glucose Control in Adults With Type 1 Diabetes Using Tirzepatide: a Randomized, Multi-center, Open-label, Non-inferiority, Parallel TrialNCT07284511
- Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1 Receptor Agonists in Chronic Kidney DiseaseNCT07309094
- Combination of Biologic and Anti-obesity Therapies in Psoriatic ArthritisNCT07443956
- Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIVNCT06935838
- Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition SubcohortNCT07567378