Closing
Do GIP/GLP-1 & amylin agonists improve cardiac & vascular function versus placebo?
Mostly studied in obesity & overweight.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity: A Placebo-Matched Randomised Controlled TrialNCT06180616 · not yet recruiting · started 2026
- Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes: a Phase 2 Double Blinded Placebo Controlled Clinical Trial (TIRTLE2)NCT06820281 · recruiting · started 2026
- The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity: A Pilot StudyNCT07218445 · recruiting · started 2026
- Fully Closed-Loop Glucose Control in Adults With Type 1 Diabetes Using Tirzepatide: a Randomized, Multi-center, Open-label, Non-inferiority, Parallel TrialNCT07284511 · recruiting · started 2026
- The Effect of Exercise and Tirzepatide on Weight and Health Outcomes (EXER-MED)NCT07298915 · not yet recruiting · started 2026
The evidence so far
- Registered trials
- 23
- With posted results
- 1
- Published papers
- 0
Of 2 decided analyses: 2 favor gip/glp-1 & amylin agonists, 0 find no difference, 0 favor the comparator.
Trials
- A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Comparing the Efficacy and Safety of Tirzepatide Versus Placebo in Patients With Heart Failure With Preserved Ejection Fraction and Obesity (SUMMIT)NCT04847557 · 4 posted results
- The Effects of Tirzepatide on Coronary Plaque Lipid Content and Myocardial Microvascular Function in Overweight and Obese People With Coronary Disease - The IDEAL-COR StudyNCT06606821
- Fully Closed-Loop Glucose Control in Adults With Type 1 Diabetes Using Tirzepatide: a Randomized, Multi-center, Open-label, Non-inferiority, Parallel TrialNCT07284511
- Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity: A Double-Blinded Randomized Controlled TrialNCT07738276
- GLIMR COPD: GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPDNCT07747805
- Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes: a Phase 2 Double Blinded Placebo Controlled Clinical Trial (TIRTLE2)NCT06820281
- Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal WomenNCT07057310
- DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot StudiesNCT07483801