Closing
Do antihypertensives improve kidney outcomes more than other treatments?
Mostly studied in chronic kidney disease.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Role of Finerenone in African American Veterans With Diabetic Kidney DiseaseNCT07155694 · not yet recruiting · started 2026
- Comparative Study on the Mode of Action of Vicadrostat and Spironolactone on Protein Profiles and Renal Hemodynamic Effects in Patients Chronic Kidney Disease…NCT07304817 · recruiting · started 2026
- Impact of Finerenone in Combination With Sodium Glucose Cotransporter-2 Inhibitor in Patients With Heart FailureNCT07351864 · not yet recruiting · started 2026
- Point-of-care Ultrasound Intervention for Tailoring Diuretic Strategy in Acute Decompensated Heart FailureNCT07469722 · not yet recruiting · started 2026
- Efficacy and Safety of Dulaglutide, SGLT-2 Inhibitors, and Finerenone Triple Therapy in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease: A…NCT07537088 · not yet recruiting · started 2026
The evidence so far
- Registered trials
- 45
- With posted results
- 5
- Published papers
- 2
Of 1 decided analyses: 1 favor antihypertensives, 0 find no difference, 0 favor the comparator.
Papers
- Is plasma renin activity a biomarker for the prediction of renal and cardiovascular outcomes in treated hypertensive patients? Observations from the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).Trial report · 2012
- The importance of proteinuria and prior cardiovascular disease in all major clinical outcomes of atherosclerotic renovascular disease - a single-center observational study.Observational study · 2016
Trials
- An Exploratory Phase 2 Study to Assess the Effect of Dapagliflozin on Glomerular Filtration Rate (GFR) in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic and Blood Pressure (BP) ControlNCT00976495 · 2 posted results
- A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKDNCT07547878
- Enhanced Diuresis and Natriuresis in Acute Decompensated Heart Failure Patients Treated With SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution: A Clinical TrialNCT06442280
- Randomised, Double Blind, Placebo Controlled Trial of Angiotensin Converting Enzyme Inhibitors and Statins in the Prevention of Long Term Complications in Young People With Type 1 DiabetesNCT01581476
- Heart Outcomes Prevention Evaluation-3NCT00468923
- Impact of Finerenone in Combination With Sodium Glucose Cotransporter-2 Inhibitor in Patients With Heart FailureNCT07351864
- Polydiuretic Therapy for Heart Failure With Preserved Ejection Fraction: A Pilot TrialNCT05129722
- Prevention of Renal and Vascular Endstage Disease Intervention TrialNCT03073018 · 1 posted result