Settled
Do antihypertensives improve lipids versus placebo?
Mostly studied in hypertension.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Very likely. So far, repeated by independent trials.
NoUnsureYes
- Belief
- 0.96 (range 0.81–1.00)
- Trials for
- 2
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Role of Finerenone in African American Veterans With Diabetic Kidney DiseaseNCT07155694 · not yet recruiting · started 2026
- Vascular Intervention Strategies Trial for Alzheimer's (VISTA)NCT07447206 · not yet recruiting · started 2026
- Efficacy and Safety of Dulaglutide, SGLT-2 Inhibitors, and Finerenone Triple Therapy in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease: A…NCT07537088 · not yet recruiting · started 2026
- A Multicenter, Randomized, Double-blind, Active-controlled, Parallel Group, Phase 3 Trial to Evaluate the Efficacy and Safety of Co-administrated HODO-2224-1…NCT06646354 · enrolling by invitation · started 2025
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical…NCT06930885 · recruiting · started 2025
The evidence so far
- Registered trials
- 80
- With posted results
- 11
- Published papers
- 9
Of 2 decided analyses: 2 favor antihypertensives, 0 find no difference, 0 favor the comparator.
Papers
- Effect of the Million Hearts Cardiovascular Disease Risk Reduction Model on Initiating and Intensifying Medications: A Prespecified Secondary Analysis of a Randomized Clinical Trial.Trial report · 2021
- Nurse-coordinated multidisciplinary, family-based cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlled trial.Trial report · 2008
- Dual-Targeted Therapy in Cardiometabolic Risk: A Meta-Analysis of Telmisartan-Based Combinations for Hypertension and Dyslipidemia.Meta-analysis / systematic review · 2025
- Coadministration of valsartan 160 and 320 mg and simvastatin 20 and 40 mg in patients with hypertension and hypercholesterolemia: a multicenter, 12-week, double-blind, double-dummy, parallel-group superiority study.Trial report · 2008
- Predictors of cholesterol treatment discussions and statin prescribing for primary cardiovascular disease prevention in community health centers.Trial report · 2016
- Electronic health record-based patient identification and individualized mailed outreach for primary cardiovascular disease prevention: a cluster randomized trial.Trial report · 2013
Trials
- Improving Equitable Acces and Adherence to Secondary Prevention Therapy With a Fixed-Dose Combination DrugNCT01321255
- Fixed Combination for Lipid and Blood Pressure Control. Randomized Cross-over StudyNCT03047538
- Cross-over Analysis of the Control of Coronary Risk Factors and Level of Platelet Inhibition With a PolypillNCT05030818
- Investigating the Effect of Renin-Angiotensin System Inhibitors in Addition to Standard Antidiabetic Therapy on Glycemic Control in Patients With Type 2 Diabetes Mellitus: A Prospective Open-label StudyNCT04707508
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical TrialNCT06930885
- Phase 1-2 Study of Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic SyndromeNCT02503865 · 1 posted result
- Nephropathy in Type 2 Diabetes: Effects of an Intensive Multifactorial Intervention Trial on Cardio-renal Events.NCT00535925 · 1 posted result
- Prevention of Renal and Vascular Endstage Disease Intervention TrialNCT03073018