Closing
Do antihypertensives improve glycemic control more than other treatments?
Mostly studied in type 2 & unspecified diabetes.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
Doubtful. So far, no trial evidence yet.
NoUnsureYes
- Belief
- 0.25 (range 0.10–0.70)
- Trials for
- 0
- Trials against
- 0
- Inconclusive
- 1
Already under way
- A Double-Blind, Randomized, Active-Controlled Phase 2a Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of TriGlytza®-01 in Overweight and…NCT07139405 · not yet recruiting · started 2026
- Role of Finerenone in African American Veterans With Diabetic Kidney DiseaseNCT07155694 · not yet recruiting · started 2026
- Efficacy and Safety of Dulaglutide, SGLT-2 Inhibitors, and Finerenone Triple Therapy in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease: A…NCT07537088 · not yet recruiting · started 2026
- A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2…NCT07547878 · not yet recruiting · started 2026
- Finerenone and Empagliflozin Combination in Obesity With Hypertension: A 12-Week Prospective, Parallel-design, Double-blind, Randomized, Placebo-controlled…NCT07678151 · not yet recruiting · started 2026
The evidence so far
- Registered trials
- 36
- With posted results
- 6
- Published papers
- 3
Of 1 decided analyses: 0 favor antihypertensives, 1 find no difference, 0 favor the comparator.
Papers
- The combination of nebivolol plus pravastatin is associated with a more beneficial metabolic profile compared to that of atenolol plus pravastatin in hypertensive patients with dyslipidemia: a pilot study.Trial report · 2003
- Moxonidine improves glycaemic control in mildly hypertensive, overweight patients: a comparison with metformin.Trial report · 2006
- Statins and risk for new-onset diabetes mellitus: A real-world cohort study using a clinical research database.Observational study · 2016
Trials
- A Pilot Randomized Clinical Trial to Assess Feasibility, Safety, and Efficacy of Rapid, Simultaneous Therapy Initiation in Chronic Kidney Disease and Type 2 Diabetes: RAPID-CKDNCT07547878
- Investigating the Effect of Renin-Angiotensin System Inhibitors in Addition to Standard Antidiabetic Therapy on Glycemic Control in Patients With Type 2 Diabetes Mellitus: A Prospective Open-label StudyNCT04707508
- Phase 1-2 Study of Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic SyndromeNCT02503865 · 1 posted result
- Polydiuretic Therapy for Heart Failure With Preserved Ejection Fraction: A Pilot TrialNCT05129722
- A Double-Blind, Randomized, Active-Controlled Phase 2a Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of TriGlytza®-01 in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin TherapyNCT07139405
- Nephropathy in Type 2 Diabetes: Effects of an Intensive Multifactorial Intervention Trial on Cardio-renal Events.NCT00535925 · 1 posted result
- Effect of Pioglitazone on Insulin Resistance, Progression of Atherosclerosis and Clinical Course of Coronary Heart DiseaseNCT03011775 · 2 posted results
- INFLAMMATION AND DRUG METABOLISM - Does the Effect of Drugs Decrease When Patients With Type 2 Diabetes Initiate Antidiabetic Treatment?NCT04504045