Closing
Do antihypertensives improve cardiovascular events versus placebo?
Mostly studied in coronary & atherosclerotic disease.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 0
Already under way
- Impact of Finerenone in Combination With Sodium Glucose Cotransporter-2 Inhibitor in Patients With Heart FailureNCT07351864 · not yet recruiting · started 2026
- Point-of-care Ultrasound Intervention for Tailoring Diuretic Strategy in Acute Decompensated Heart FailureNCT07469722 · not yet recruiting · started 2026
- Efficacy and Safety of Dulaglutide, SGLT-2 Inhibitors, and Finerenone Triple Therapy in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease: A…NCT07537088 · not yet recruiting · started 2026
- DELayed Initiation of ARNI and SGLT2i in Heart Failure With Corrected aetiologY (DELAY-HF), Pilot StudyNCT07572032 · recruiting · started 2026
- A Phase III, Randomised, Placebo-controlled, Event-driven Study to Evaluate the Effect of Baxdrostat in Combination With Dapagliflozin Compared With…NCT06677060 · recruiting · started 2025
The evidence so far
- Registered trials
- 38
- With posted results
- 6
- Published papers
- 5
Of 2 decided analyses: 2 favor antihypertensives, 0 find no difference, 0 favor the comparator.
Papers
- Effect of Combined Statin and Antihypertensive Therapy in Patients with Hypertension: A Systematic Review and Meta-Analysis.Meta-analysis / systematic review · 2020
- Role of cardioprotective therapy for prevention of cardiotoxicity with chemotherapy: a systematic review and meta-analysis.Meta-analysis / systematic review · 2013
- Interventions for preventing cardiomyopathy due to anthracyclines: a Bayesian network meta-analysis.Meta-analysis / systematic review · 2017
- Effect of Metformin on Renal Function After Primary Percutaneous Coronary Intervention in Patients Without Diabetes Presenting with ST-elevation Myocardial Infarction: Data from the GIPS-III Trial.Trial report · 2015
- Effectiveness of Levoamlodipine Maleate for Hypertension Compared with Amlodipine Besylate: a Pragmatic Comparative Effectiveness Study.Trial report · 2021
Trials
- Heart Outcomes Prevention Evaluation-3NCT00468923 · 2 posted results
- A Randomized, Open-label Study of Dapagliflozin in Patients With or Without Type 2 Diabetes Admitted With Acute Heart FailureNCT04298229 · 1 posted result
- PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial.NCT05122780
- Efficacy and Safety of Chinese Herbal Medicine Wen Xin Granules for the Treatment of Unstable Angina Pectoris With Yang Deficiency and Blood Stasis Syndrome: Study Protocol for a Randomized Controlled TrialNCT04661709
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical TrialNCT06930885
- Impact of Finerenone in Combination With Sodium Glucose Cotransporter-2 Inhibitor in Patients With Heart FailureNCT07351864
- Carotid Endarterectomy Versus Optimal Medical Treatment of Asymptomatic High Grade Carotid Artery StenosisNCT00805311
- Nephropathy in Type 2 Diabetes: Effects of an Intensive Multifactorial Intervention Trial on Cardio-renal Events.NCT00535925 · 1 posted result