Closing
Do antihypertensives improve blood pressure versus placebo?
Mostly studied in hypertension. Also asked against other treatments.
Not modeled yetTrial evidence exists, but no mechanistic model yetWithout a model there is no decisive experiment to propose. Help build it. →
Where the evidence stands
A coin flip. So far, one result, not yet repeated.
NoUnsureYes
- Belief
- 0.50 (range 0.25–0.70)
- Trials for
- 1
- Trials against
- 0
- Inconclusive
- 1
Already under way
- Vascular Intervention Strategies Trial for Alzheimer's (VISTA)NCT07447206 · not yet recruiting · started 2026
- Finerenone and Empagliflozin Combination in Obesity With Hypertension: A 12-Week Prospective, Parallel-design, Double-blind, Randomized, Placebo-controlled…NCT07678151 · not yet recruiting · started 2026
- QUAdruple Therapy With RASi, Empagliflozin, Finerenone, and Mazdutide in Type 2 Diabetes and Early Treatment of Nephropathy(QUARTET-DKD)NCT07775846 · not yet recruiting · started 2026
- A Multicenter, Randomized, Double-blind, Active-controlled, Parallel Group, Phase 3 Trial to Evaluate the Efficacy and Safety of Co-administrated HODO-2224-1…NCT06646354 · enrolling by invitation · started 2025
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical…NCT06930885 · recruiting · started 2025
The evidence so far
- Registered trials
- 89
- With posted results
- 11
- Published papers
- 11
Of 7 decided analyses: 2 favor antihypertensives, 4 find no difference, 1 favor the comparator.
Papers
- Effect of the Million Hearts Cardiovascular Disease Risk Reduction Model on Initiating and Intensifying Medications: A Prespecified Secondary Analysis of a Randomized Clinical Trial.Trial report · 2021
- A pilot randomized clinical trial of gamification to increase medication adherence.Trial report · 2026
- Pharmacological interventions for asymptomatic carotid stenosis.Meta-analysis / systematic review · 2023
- Dual-Targeted Therapy in Cardiometabolic Risk: A Meta-Analysis of Telmisartan-Based Combinations for Hypertension and Dyslipidemia.Meta-analysis / systematic review · 2025
- Should we add atorvastatin to irbesartan for improving renoprotective effects in early diabetic nephropathy? A meta-analysis of randomized controlled trials.Meta-analysis / systematic review · 2019
- Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong).Trial report · 2016
Trials
- An Exploratory Phase 2 Study to Assess the Effect of Dapagliflozin on Glomerular Filtration Rate (GFR) in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic and Blood Pressure (BP) ControlNCT00976495 · 6 posted results
- Improving Equitable Acces and Adherence to Secondary Prevention Therapy With a Fixed-Dose Combination DrugNCT01321255
- Fixed Combination for Lipid and Blood Pressure Control. Randomized Cross-over StudyNCT03047538
- "An Open-label Clinical Trial to Evaluate the Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan in Adult Patients With Chronic Heart Failure With Reduced Ejection Fraction Associated With Congenital Heart Disease"NCT05580510
- Cross-over Analysis of the Control of Coronary Risk Factors and Level of Platelet Inhibition With a PolypillNCT05030818
- Investigating the Effect of Renin-Angiotensin System Inhibitors in Addition to Standard Antidiabetic Therapy on Glycemic Control in Patients With Type 2 Diabetes Mellitus: A Prospective Open-label StudyNCT04707508
- Evaluation of a POlypill and Colchicine for Risk Reduction in Patients With Established Atherosclerotic Cardiovascular Disease: The EPOCA Randomized Clinical TrialNCT06930885
- Late Percutaneous Coronary Intervention of the Occluded Infarct-Related Artery in Patients With Preserved Infarct Zone Viability Determined With Magnetic Resonance ImagingNCT00968383