← GLP-1 receptor agonists × glycemic control

TrialObesity (Silver Spring, Md.)2023

Weight loss maintenance with exercise and liraglutide improves glucose tolerance, glucagon response, and beta cell function.

Simon B K Jensen et al.PubMed ↗Publisher ↗

  • Liraglutide alonelooks good hereLower postprandial glucose response.Randomised, small.
  • Combination of exercise and liraglutidelooks good hereLower postprandial glucose response, higher beta cell function, lower glucagon response.Randomised, small.

What the trial testedrandomised · 195 people · 2023

Randomised vs placebo

Probably lowered postprandial glucose response

−7.00percentage points−12.0 to −1.00

liraglutide alone vs placebo

As reported

difference −7 %, 95% CI −12.0 to −1.00

Randomised vs placebo

Probably lowered postprandial glucose response

−9.00percentage points−14.0 to −3.00

combination of exercise and liraglutide vs placebo

As reported

difference −9 %, 95% CI −14.0 to −3.00

Randomised vs placebo

Probably raised beta cell function

+49.0percentage points+16.0 to +93.0

combination of exercise and liraglutide vs placebo

As reported

difference 49 %, 95% CI 16.0–93.0

Not counted

Probably lowered glucagon response

−18.0percentage points−34.0 to −3.00

combination of exercise and liraglutide vs placebo

As reported

difference −18 %, 95% CI −34.0 to −3.00

Who was studied, and how

195people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

liraglutide alone
placebo

Probably lowered postprandial glucose response−7.00

randomised

The trial randomly assignedassigned by chance

combination of exercise and liraglutide
placebo

Probably lowered postprandial glucose response−9.00

Probably raised beta cell function+49.0

Probably lowered glucagon response−18.0

randomised

the abstract, start to end

… postprandial glucose response by -7% (95% CI: -12% to -1%; p = …

… postprandial glucose response by -9% (95% CI: -14% to -3%; p = 0.002), improved beta cell function by 49% (95% CI: 16% to 93%; p = 0.002), and decreased glucagon response by -18% (95% CI: -34% to -3%; p = …

← favours treatmentfavours comparator →
could be chance
Postprandial glucose responseliraglutide alone vs placebo
−7−12.0 to −1.00
Postprandial glucose responsecombination of exercise and liraglutide vs placebo
−9−14.0 to −3.00
Beta cell functioncombination of exercise and liraglutide vs placebo
4916.0–93.0
Glucagon responsecombination of exercise and liraglutide vs placebo
−18−34.0 to −3.00
GLP-1 receptor agonistsDiet, exercise & lifestyleGlycemic control

GLP-1 receptor agonists × glycemic controlhelps?replicated

unlikelylikely
0.900.90 without it

Diet, exercise & lifestyle × glycemic controlhelps?replicated

unlikelylikely
0.990.50 without it
← favours comparatorfavours treatment →
this papermore certainless certain
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11 papers cite it

2023
2024
2025
2026
this papertrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 36942420