Evidence map›Paper›PMID 9490243›Full record

ArticleCirculation1998

Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion.

K Wei, A R Jayaweera, S Firoozan, A Linka, D M Skyba, S Kaul

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Circulation, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 402 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
402citing papers in PubMed, 2 pooled it
55.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 21610226PMID 34339111PMID 34075130PMID 33259257PMID 33219433PMID 33184152other papers from this trial
Open the trial in the graph
NCT03520569 early_phase1completednot on this mapstarted 2019, after this paper: background citation

Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults

TypeinterventionalSponsorUniversity of VirginiaRan2019 to 2021Enrolled15ConditionsVascular Stiffness, Insulin SensitivityArmsOctreotide, Insulin, Dextrose 20% solution
3 · Its place in the literature

Who cites it

402 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,605 citations in OpenAlex.

  1. Utility of Contrast-Enhanced Ultrasound for the Assessment of Skeletal Muscle Perfusion in Diabetes Mellitus: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
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  13. Blood flow after exercise-induced muscle damage.Journal of athletic training · 2015
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342 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

K WeiCardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA.
A R Jayaweera
S Firoozan
A Linka
D M Skyba
S Kaul
University of Virginia · US

Funding

Genetic variation and biomarkers in children with acute lung injuryR01HL095410 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAHMER, MARY K, FLORI, HEIDI R · 2009 to 2012
$1.8M
ECHOCARDIOGRAPHIC ASSESSMENT OF MYOCARDIAL PERFUSIONR01HL048890 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KAUL, SANJIV · 1992 to 2002
$1.0M
NHLBI NIH HHS F32-HL-095410NHLBI NIH HHS R01-HL-48890
6 · The paper itself

Abstract

backgroundUltrasound can cause microbubble destruction. If microbubbles are administered as a continuous infusion, then their destruction within the myocardium and measurement of their myocardial reappearance rate at steady state will provide a measure of mean myocardial microbubble velocity. Conversely, measurement of their myocardial concentration at steady state will provide an assessment of microvascular cross-sectional area. Myocardial blood flow (MBF) can then be calculated from the product of the two. METHODS AND

resultsEx vivo and in vitro experiments were performed in which either flow was held constant and pulsing interval (interval between microbubble destruction and replenishment) was altered, or vice versa. In vivo experiments were performed in 21 dogs. In group 1 dogs (n=7), MBF was mechanically altered in a model in which coronary blood volume was constant. In group 2 dogs (n=5), MBF was altered by direct coronary infusions of vasodilators. In group 3 dogs (n=9), non-flow-limiting coronary stenoses were created, and MBF was measured before and after the venous administration of a coronary vasodilator. In all experiments, microbubbles were delivered as a constant infusion, and myocardial contrast echocardiography was performed using different pulsing intervals. The myocardial video intensity versus pulsing interval plots were fitted to an exponential function: y=A(1-e[-betat]), where A is the plateau video intensity reflecting the microvascular cross-sectional area, and beta reflects the rate of rise of video intensity and, hence, microbubble velocity. Excellent correlations were found between flow and beta, as well as flow and the product of A and beta.

conclusionsMBF can be quantified with myocardial contrast echocardiography during a venous infusion of microbubbles. This novel approach has potential for measuring tissue perfusion in any organ accessible to ultrasound.

Indexed as

SonicationAnimalsContrast MediaCoronary CirculationCoronary VesselsDogsEchocardiographyHeartHemodynamicsInfusions, IntravenousIn Vitro TechniquesMicrospheresModels, CardiovascularContrast Media

Identifiers

PMID9490243
OpenAlexW2125048739

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.