ArticleThe EMBO journal1997
Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 113 citations in OpenAlex.
- Changes in Evolutionary Developmental Control Points in the Amniote Limb May Explain Hyperphalangy.Molecular biology and evolution · 2025Article
- A timed epigenetic switch balances T and ILC lineage proportions in the thymus.Development (Cambridge, England) · 2024Article
- Variation in the sacrum of phytosaurs: New evidence from a partial skeleton of Machaeroprosopus mccauleyi.Journal of anatomy · 2024Article
- Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.Journal of anatomy · 2022Review
- Regulatory modules mediating the complex neural expression patterns of the homeobrain gene during Drosophila brain development.Hereditas · 2022Article
- Annotation of Hox cluster and Hox cofactor genes in the Asian citrus psyllid,GigaByte (Hong Kong, China) · 2022Article
- Scalable control of developmental timetables by epigenetic switching networks.Journal of the Royal Society, Interface · 2021Article
- Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans.Genetics · 2019Article
- Sacral anatomy of the phytosaur Smilosuchus adamanensis, with implications for pelvic girdle evolution among Archosauriformes.Journal of anatomy · 2017Article
- Hox genes in the adult skeleton: Novel functions beyond embryonic development.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord.Nature communications · 2017Article
- A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior.PLoS genetics · 2016Article
- Hoxa5: A Key Player in Development and Disease.Journal of developmental biology · 2016Review
- Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination.Journal of neurochemistry · 2013Article
- The chromatin insulator CTCF and the emergence of metazoan diversity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Transcriptional neoteny in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Uncoupling time and space in the collinear regulation of Hox genes.PLoS genetics · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A phylogenetically conserved transcriptional enhancer necessary for the activation of Hoxd-11 was deleted from the HoxD complex of mice by targeted mutagenesis. While genetic and expression analyses demonstrated the role of this regulatory element in the activation of Hoxd-11 during early somitogenesis, the function of this gene in developing limbs and the urogenital system was not affected, suggesting that Hox transcriptional controls are different in different axial structures. In the trunk of mutant embryos, transcriptional activation of Hoxd-11 and Hoxd-10 was severely delayed, but subsequently resumed with appropriate spatial distributions. The resulting caudal transposition of the sacrum indicates that proper vertebral specification requires a precise temporal control of Hox gene expression, in addition to spatial regulation. A slight time delay in expression (transcriptional heterochrony) cannot be compensated for at a later developmental stage, eventually leading to morphological alterations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.