ReviewAntonie van Leeuwenhoek1996
The proteolytic systems of lactic acid bacteria.
Review in Antonie van Leeuwenhoek, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
146 citing papers in PubMed, 707 citations in OpenAlex.
- Sourdough bread made from wheat and nontoxic flours and started with selected lactobacilli is tolerated in celiac sprue patients.Applied and environmental microbiology · 2004Trial
- Proteolytic Activity of Commercial Thermophilic Starter Cultures and Changes in Protein Fractions and Free Amino Acids in Organic and Conventional Fermented Milk.Food science & nutrition · 2026Article
- Lactobacilli-Fermented Chia Seeds as a Potential Anti-Hypertensive Agent.Molecules (Basel, Switzerland) · 2026Article
- Engineering Streptococcus thermophilus for heterologous gene expression of cell envelope proteases from lactic acid bacteria.Microbial cell factories · 2026Article
- Peptide Profiling of Young Gouda Holland Cheese and Its Digests Obtained by In-Vitro-Simulated Gastrointestinal Digestion.Journal of agricultural and food chemistry · 2025Article
- Profiling protein hydrolysis and amino acid metabolism in camel and bovine milk fermented by Lactobacillus helveticus, L. bulgaricus, and Streptococcus thermophilus.Scientific reports · 2025Article
- A novel selective medium for isolation of Limosilactobacillus reuteri from dietary supplements.Journal of food and drug analysis · 2024Article
- Determination of Technological Properties and CRISPR Profiles ofMicroorganisms · 2024Article
- Functional Characterization of DifferentFoods (Basel, Switzerland) · 2024Article
- Deciphering the metabolism ofApplied and environmental microbiology · 2024Article
- An Apple and Acáchul Berry Snack Rich in Bioaccessible Antioxidants and Folic Acid: A Healthy Alternative for Prenatal Diets.Foods (Basel, Switzerland) · 2024Article
- Microbial interactions shape cheese flavour formation.Nature communications · 2023Article
- Characterization of an Aminopeptidase A fromJournal of microbiology and biotechnology · 2023Article
- Technological Characterization of Lactic Acid Bacteria Strains for Potential Use in Cheese Manufacture.Foods (Basel, Switzerland) · 2023Article
- Characterization of a highly conserved MUC5B-degrading protease, MdpL, fromFrontiers in microbiology · 2023Article
- Synergistic fermentation ofFood chemistry: X · 2022Article
- Characterization of Angiotensin I-Converting Enzyme (ACE) inhibitory peptides produced in fermented camel milk (Indian breed) byJournal of food science and technology · 2022Article
- Differential Amino Acid Uptake and Depletion in Mono-Cultures and Co-Cultures ofMicroorganisms · 2022Article
- Microbial Ecology of Sheep Milk, Artisanal Feta, and Kefalograviera Cheeses. Part II: Technological, Safety, and Probiotic Attributes of Lactic Acid Bacteria Isolates.Foods (Basel, Switzerland) · 2022Article
- Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proteolysis in dairy lactic acid bacteria has been studied in great detail by genetic, biochemical and ultrastructural methods. From these studies the picture emerges that the proteolytic systems of lactococci and lactobacilli are remarkably similar in their components and mode of action. The proteolytic system consists of an extracellularly located serine-proteinase, transport systems specific for di-tripeptides and oligopeptides (> 3 residues), and a multitude of intracellular peptidases. This review describes the properties and regulation of individual components as well as studies that have led to identification of their cellular localization. Targeted mutational techniques developed in recent years have made it possible to investigate the role of individual and combinations of enzymes in vivo. Based on these results as well as in vitro studies of the enzymes and transporters, a model for the proteolytic pathway is proposed. The main features are: (i) proteinases have a broad specificity and are capable of releasing a large number of different oligopeptides, of which a large fraction falls in the range of 4 to 8 amino acid residues; (ii) oligopeptide transport is the main route for nitrogen entry into the cell; (iii) all peptidases are located intracellularly and concerted action of peptidases is required for complete degradation of accumulated peptides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.