Evidence map›Paper›PMID 42643162›Full record

ArticleFood chemistry: X2026

Comparative enzymatic hydrolysis of porcine tracheal cartilage generates ACE/DPP-IV-inhibitory and antioxidant peptides with enhanced bioactivity following simulated gastrointestinal digestion and molecular docking analysis.

Rayudika Aprilia Patindra Purba, Suchanya Sinsranoi, Phanthipha Laosam, Phornpilat Senanok, Pichitpon Luasiri, Pornphutthachat Sota, Nattapol Pongsamai, Saranya Suwanangul, Jukkrapong Pinyo, Sasikan Katemala and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rayudika Aprilia Patindra PurbaDepartment of Agricultural Science and Technology, Faculty of Innovative Agriculture, Fisheries and Food, Prince of Songkla University, Surat Thani Campus, Surat Thani, 84000, Thailand.
Suchanya SinsranoiResearch and Development Institute Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Phanthipha LaosamResearch and Development Institute Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Phornpilat SenanokPostharvest Technology and Innovation in Animal Unit, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Pichitpon LuasiriPostharvest Technology and Innovation in Animal Unit, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Pornphutthachat SotaSchool of Animal Technology and Innovation, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Nattapol PongsamaiSuranaree University of Technology Hospital, Nakhon Ratchasima 30000, Thailand.
Saranya SuwanangulProgram in Food Science and Technology, Faculty of Engineering and Agro-industry, Maejo University, Chiang Mai 50290, Thailand.
Jukkrapong PinyoFaculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand.
Sasikan KatemalaFaculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand.
Saruttiwong BoonkongPostharvest Technology and Innovation in Animal Unit, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Kamonpan SanachaiDepartment of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Papungkorn SangsawadPostharvest Technology and Innovation in Animal Unit, Institute of Agricultural Technology, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porcine tracheal cartilage, an underutilized Type II collagen-rich by-product, was systematically evaluated as a source of angiotensin I-converting enzyme (ACE) inhibitory, dipeptidyl peptidase-IV (DPP-IV) inhibitory, and antioxidant peptides. Neutrase at 4 h outperformed Papain in generating ACE-inhibitory and antioxidant peptides. The <3 kDa ultrafiltration fraction, enriched in small hydrophobic peptides, exhibited the highest bioactivities. LC-MS/MS identified eight sequences (870-1565 Da). Chemical synthesis confirmed LGLGADMFHR as the most potent ACE inhibitor (IC

Indexed as

Angiotensin-converting enzyme inhibitionAntioxidant activityBioactive peptidesDipeptidyl peptidase-IV inhibitionEnzymatic hydrolysisIn vitro gastrointestinal digestionPorcine tracheal cartilage

Identifiers

PMID42643162
PMCPMC13503080

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.