Evidence map›Paper›PMID 42548389›Full record

ArticleCHEST pulmonary2025

Spot On: Indocyanine Green-Soaked Fiducial Markers for Lung Nodules Prior to Thoracic Surgery.

Bryan S Benn, Hasnain Bawaadam, Elizabeth M Colwell, Matthew D Peterson, William B Tisol, Abesh Niroula, Wissam S Jaber, Onkar V Khullar, Kelly Daymude, Chinh T Phan and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CHEST pulmonary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Bryan S BennDepartment of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH.
Hasnain BawaadamDepartment of Interventional Pulmonary and Critical Care Medicine, Advocate Aurora Medical Center, Kenosha, WI.
Elizabeth M ColwellDepartment of Cardiothoracic Surgery, Advocate Aurora St Lukes Medical Center, Milwaukee, WI.
Matthew D PetersonDepartment of Interventional Pulmonary and Critical Care Medicine, Advocate Aurora Medical Center, Kenosha, WI.
William B TisolDepartment of Cardiothoracic Surgery, Advocate Aurora St Lukes Medical Center, Milwaukee, WI.
Abesh NiroulaDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA.
Wissam S JaberDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine, Atlanta, GA.
Onkar V KhullarDivision of Cardiothoracic Surgery, Emory University, Atlanta, GA.
Kelly DaymudeEmory Healthcare, Atlanta, GA.
Chinh T PhanDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Sacramento, CA.
Luis A GodoyDivision of General Thoracic Surgery, Department of Surgery, University of California, Davis Health, Sacramento, CA.
Devon AndersonDivision of General Thoracic Surgery, Department of Surgery, University of California, Davis Health, Sacramento, CA.
Michelle LaganaDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Sacramento, CA.
Elizabeth A YuDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, CA.
Tomomi OkaDepartment of Cardiothoracic Surgery, Palo Alto Medical Foundation, Palo Alto, CA.
Mendy LumRespiratory Medicine, El Camino Hospital, Mountain View, CA.
Pallav L ShahRoyal Brompton Hospital, London, England.
Ganesh KrishnaDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Peripheral pulmonary lesions (PPLs) are increasingly identified and often require a tissue diagnosis to guide treatment. Although a surgical resection may combine diagnosis and treatment, it may lead to excessive healthy tissue being removed if the lesion is difficult to localize. Bronchoscopic PPL marking before surgery facilitates this process, but it is limited by current technologies. Advances in procedural techniques may improve this process. Research Question: What is the impact of using indocyanine green-soaked fiducial markers (ICG-Fs) to mark PPLs before surgery compared with unmarked resected PPLs? Study Design and Methods: A retrospective review of patients from 4 institutions with PPLs undergoing bronchoscopy with ICG-F marking (54 nodules) before resection were compared with unmarked nodules (63 nodules). Demographic data, nodule characteristics, procedural and surgical information, and final pathology results were obtained. Results: Demographics were similar between the groups. PPLs were smaller in the ICG-F marked group (axial: ICG-F marked: 14.39 ± 5.39 vs unmarked: 20.31 ± 14.24 mm; Interpretation: Our findings indicate that ICG-F is a safe and accurate procedure to facilitate lung sparing surgery of otherwise undetectable PPLs immediately after bronchoscopic placement or up to 13 days later.

Indexed as

dye markingfiducial makerindocyanine greenlung nodulelung surgery

Identifiers

PMID42548389
PMCPMC13418667

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.