ArticleFood chemistry. Molecular sciences2026
A key SNP in the flavonoid biosynthesis pathway gene CsaV3_6G009030 is highly correlated with cucumber fruit bitterness.
Article in Food chemistry. Molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cucumber fruit bitterness is a prominent issue affecting fruit quality and seriously compromises the commercial value of cucumbers. In this study, near-isogenic lines (NILs) were developed through six consecutive backcross generations using the bitter cucumber inbred line '5' (P2) as the recurrent parent and the non-bitter cucumber inbred line 'WK15' (P1) as the donor parent, generating a BC6F2 population. Bulk segregant RNA-seq (BSR-seq) combined with metabolomics analysis was performed to screen for candidate regions and metabolic pathways significantly associated with fruit bitterness. A 5.8 Mb (2.7-8.5 Mb) candidate region for bitterness was mapped to chromosome 6. Functional analysis of the target region revealed significant enrichment of the flavonoid biosynthesis pathway. Metabolic network analysis indicated that six flavonoid differential metabolites, including 4-methoxycinnamic acid and 2'-hydroxychalcone, were significantly enriched in bitter cucumbers, and their expression levels were highly consistent with the bitter phenotype. Through gene functional annotation and SNP validation, a key gene,
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