ArticleEFSA journal. European Food Safety Authority2011
Scientific Opinion on the substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease pursuant to Article 14 of Regulation (EC) No 1924/2006.
Article in EFSA journal. European Food Safety Authority, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Trial
- Trial
- Cereal Arabinoxylans-Their Enzymatic Degradation and Relevance for Breadmaking and Human Health.Comprehensive reviews in food science and food safety · 2026Review
- Effect of Neutral and Acidic Protease Processing Intervals on Optimising Nutritional Value and Enhancing Physico-Chemical Properties of Oat Drink.Foods (Basel, Switzerland) · 2024Article
- Dietary Fibre for the Prevention of Post-Pancreatitis Diabetes Mellitus: A Review of the Literature and Future Research Directions.Nutrients · 2024Review
- Article
- A New Functional Wheat Flour Flatbread (Bazlama) Enriched with High-β-Glucan Hull-Less Barley Flour.Foods (Basel, Switzerland) · 2024Article
- Sequential Extraction and Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy Monitoring in the Biorefining of Brewer's Spent Grain.Molecules (Basel, Switzerland) · 2023Article
- Influence of Hydrothermal Treatment of Brewer's Spent Grain on the Concentration and Molecular Weight Distribution of 1,3-1,4-β-D-Glucan and Arabinoxylan.Foods (Basel, Switzerland) · 2023Article
- Review
- Dietary fiber - a scoping review for Nordic Nutrition Recommendations 2023.Food & nutrition research · 2023Article
- Barley in the Production of Cereal-Based Products.Plants (Basel, Switzerland) · 2022Review
- The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System.International journal of molecular sciences · 2022Review
- Effect of the Addition of Hulless Barley Flour on the Quality of Short-Dough Cookies.Foods (Basel, Switzerland) · 2022Article
- Quality Assessment of Cookies Made from Composite Flours Containing Malted Barley Flour and Wheat Flour.Plants (Basel, Switzerland) · 2022Article
- "Planeterranea": An attempt to broaden the beneficial effects of the Mediterranean diet worldwide.Frontiers in nutrition · 2022Review
- Process-Induced Changes in the Quantity and Characteristics of Grain Dietary Fiber.Foods (Basel, Switzerland) · 2021Review
- Polysaccharide Structures and Their Hypocholesterolemic Potential.Molecules (Basel, Switzerland) · 2021Review
- Dietary Fiber: An Opportunity for a Global Control of Hyperlipidemia.Oxidative medicine and cellular longevity · 2021Review
- Effect of High β-glucan Barley on Postprandial Blood Glucose and Insulin Levels in Type 2 Diabetic Patients.Clinical nutrition research · 2020Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following an application from Cargill Incorporated submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Belgium, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to barley beta-glucans and lowering of blood cholesterol and reduced risk of (coronary) heart disease, referring to disease risk reduction and including a request for the protection of proprietary data. The food constituent that is the subject of the health claim, barley beta-glucans, is sufficiently characterised. Lowering blood LDL-cholesterol concentration is a beneficial physiological effect by decreasing the risk of coronary heart disease. The applicant identified a total of 16 references as being pertinent to the health claim. These references comprised three meta-analyses, 10 human intervention studies, two animal studies and one mechanistic study. In weighing the evidence, the Panel took into account that one meta-analysis including 11 RCTs and one additional RCT which investigated the effects of barley beta-glucans at doses of at least 3 g/day showed a decrease in total and LDL-cholesterol concentrations in both normo- and hypercholesterolaemic subjects, and that the mechanism by which barley beta-glucans could exert the claimed effect is biologically plausible and supported by the animal studies provided. The Panel concludes that a cause and effect relationship has been established between the consumption of barley beta-glucans and the lowering of blood LDL-cholesterol concentrations. The following wording reflects the scientific evidence: "Barley beta-glucans have been shown to lower/reduce blood cholesterol. High cholesterol is a risk factor in the development of coronary heart disease". At least 3 g of barley beta-glucans should be consumed per day in order to obtain the claimed effect. The target population is adults who want to lower their blood cholesterol concentrations.
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Registered trials
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