Evidence map›Paper›PMID 41174715›Full record

SynthesisJournal of physiological anthropology2025

Dietary interventions in skin ageing: a systematic review and meta-analysis.

Jun Yan Ng, Xuan Min Gail Yan Ng, Qi Yi Ambrose Wong, Fook Tim Chew

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of physiological anthropology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jun Yan NgDepartment of Biological Sciences, Faculty of Science, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore, 117543, Singapore.ORCID http://orcid.org/0000-0003-2548-397X
Xuan Min Gail Yan NgDepartment of Biological Sciences, Faculty of Science, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore, 117543, Singapore.ORCID http://orcid.org/0009-0008-5387-6504
Qi Yi Ambrose WongDepartment of Biological Sciences, Faculty of Science, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore, 117543, Singapore.ORCID http://orcid.org/0009-0000-5205-4033
Fook Tim ChewDepartment of Biological Sciences, Faculty of Science, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore, 117543, Singapore. dbscft@nus.edu.sg.ORCID http://orcid.org/0000-0003-1337-5146

Funding

Agency for Science Technology and Research (A*STAR) (Singapore) H17/01/a0/008Biomedical Research Council (BMRC) (Singapore) BMRC/01/1/21/18/077National Medical Research Council (NMRC) (Singapore) NMRC/1150/2008National Research Foundation (NRF) (Singapore) NRF-MP-2020-0004National University of Singapore N-154-000-038-001Singapore Food Agency (SFA) SFS_RND_SUFP_001_04Singapore Immunology Network SIgN-06-006Singapore Ministry of Education Academic Research Fund R-154-000-191-112Singapore's Economic Development Board (EDB) A-8002576-00-00
6 · The paper itself

Abstract

backgroundNutrition is a modifiable factor in skin ageing, but its effects remain inconsistently quantified. This meta-analysis assessed human studies from the Web of Science on dietary intake and skin ageing, using pooled standardised mean differences (pSMD). Interventions included carotenoids, collagen, lipids and fatty acids, polyphenols, prebiotics and probiotics, and vitamins. We included full-text English articles and excluded non-human, disease-focused, topical or in vitro studies. Publication bias was assessed using Egger's test and funnel plots. Results are shown as forest plots. MAIN BODY: Sixty-one studies were meta-analysed. Collagen reduces wrinkles (pSMD = - 0.94 [- 1.39, - 0.49], p = 4.82 × 10

conclusionDietary components target specific skin ageing phenotypes. Carotenoids, collagen, lipids and fatty acids, and polyphenols are particularly effective for redness, pigment spots, elasticity, and barrier integrity, respectively. Lipids, fatty acids, and polyphenols show broad benefits across multiple phenotypes. Shared mechanisms may contribute to overlapping effects. Evidence gaps remain, especially regarding carotenoids and vitamins. Future studies could explore combinatorial dietary interventions. This research is primarily supported by a Singapore National Medical Research Council grant.

Indexed as

DietSkin AgingCollagenHumansPolyphenolsCollagenPolyphenolsdietelasticityhydrationinterventionmeta-analysisnutritionskin ageingskin agingsystematic reviewwrinkling

Identifiers

PMID41174715
PMCPMC12577306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.