Evidence map›Paper›PMID 40617511›Full record

ArticleThe Journal of nutrition2025

Cognitive Impairment Is Associated with Alterations in Diet Quality and Inflammatory Biomarkers in Older Adults: A Cross-Sectional Analysis of Data Collected from the Microbiome in Aging Gut and Brain (MiaGB) Consortium Cohort.

Andrea Y Arikawa, Anna Waterman, Sidharth P Mishra, Corinne Labyak, Cynthia Williams, Diptaraj S Chaudhari, Rohit Shukla, Vivek Kumar, Michal Masternak, Peter Holland and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Andrea Y ArikawaDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, United States. Electronic address: a.arikawa@unf.edu.
Anna WatermanDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, United States.
Sidharth P MishraUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Corinne LabyakDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, United States.
Cynthia WilliamsUniversity of Central Florida School of Global Health Management and Informatics, Orlando, FL, United States.
Diptaraj S ChaudhariUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Rohit ShuklaUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Vivek KumarUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Michal MasternakBurnett School of Biomedical Sciences, University of Central Florida College of Medicine, Orlando, FL, United States; Department of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland.
Peter HollandDepartment of Neuroscience, Florida Atlantic University Schmidt College of Medicine, Boca Raton, FL, United States.
Adam GoldenOrlando Veterans Affairs Healthcare System, Orlando, FL, United States; Department of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, United States.
Mariana DangioloDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, United States.
Judyta KociolekClinical Research Unit, Division of Research, Florida Atlantic University, Boca Raton, FL, United States.
Amoy FraserDepartment of Internal Medicine, University of Central Florida College of Medicine, Orlando, FL, United States.
Marc AgroninBehavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, United States.
Mariolga AymatBehavioral Health, MIND Institute, Miami Jewish Health, Miami, FL, United States.
Hariom YadavUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Shalini JainUSF Center for Microbiome Research, Microbiomes Institute, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Center for Excellence in Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.

Funding

Saliva based protein markers for predicting the risk of cognitive decline and dementia in older adults.R21AG082164 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI JAIN, SHALINI · 2023 to 2024
$412k
NIA NIH HHS R21 AG082164
6 · The paper itself

Abstract

backgroundResearch suggests that gut inflammation and alterations in intestinal barrier function may be important mechanisms linking diet, systemic inflammation, and cognitive outcomes.

objectivesThe objective of this study was to explore the relationship between diet, cognitive health, and inflammatory markers in older adults. It was hypothesized that cognitive impairment would be associated with lower diet quality and higher levels of inflammatory markers.

methodsA cross-sectional analysis was conducted using data from the microbiome in aging gut and brain consortium cohort. Participants aged 60 y and older were assessed for cognitive status using the Montreal Cognitive Assessment (MoCA), diet quality using the Healthy Eating Index-2020 (HEI-2020), and dietary inflammatory potential using the dietary inflammatory index (DII). Inflammatory biomarkers were measured in plasma and stool samples, including interleukin (IL)-6, IL-1β, lipopolysaccharide-binding protein (LBP), toll-like receptor 4 (TLR4), and zonula occludens-1 (ZO-1).

resultsAmong 217 participants, 33.6% presented with cognitive impairment based on MoCA scores. There were no differences in DII and HEI-2020 scores between participants with and without cognitive impairment. The only significant finding related to the components of the HEI was a higher adequacy of dairy intake in those without cognitive impairment (54.8%) compared with those with cognitive impairment (44.4%, P = 0.035). Key inflammatory markers, including IL-6, IL-1β, LBP, and TLR4, were elevated in those with cognitive impairment, whereas plasma ZO-1 levels were reduced. Stool calprotectin levels were notably higher in those with cognitive impairment, suggesting increased intestinal inflammation. There was a weak but significant correlation between stool calprotectin and DII score (r

conclusionsThe findings suggest that elevated inflammatory markers and disrupted intestinal barrier integrity may contribute to cognitive decline. These results highlight the need to develop dietary interventions to mitigate cognitive impairment through modulation of inflammation.

Indexed as

calprotectincognitionC-reactive proteindietary inflammatory indexolder adultstight junction proteinzonula occludens-1

Identifiers

PMID40617511
PMCPMC12424083

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.