ArticleDiabetes research and clinical practice2025
Trends of lower-limb complications in patients with type 2 diabetes mellitus during the COVID-19 pandemic.
Article in Diabetes research and clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Lower extremity amputations in Switzerland: Trends in patients with and without diabetes, 2013-2023.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Reamputation risk and mortality after lower-limb amputation in patients with diabetes: predictors, effects of antidiabetic medications and temporal trends.Cardiovascular diabetology · 2026 · on this mapObservational
- Clinical applications of machine learning for infection assessment in diabetic foot ulcers.Frontiers in physiology · 2026Review
- Intravitreal anti-VEGF therapy and risk of limb complications in individuals with diabetic eye disease.Diabetes research and clinical practice · 2025Article
- Effects of the type and quality of usual source of care on medical expenditures in adults with diabetes before and during the COVID‑19 pandemic: a panel data analysis using the Korea Health Panel (2019-2022).BMC health services research · 2025Article
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8 authors.
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Abstract
aimsThe long-term impact of the COVID-19 pandemic on lower limb complications remains unclear. We aimed to assess the effect of the COVID-19 pandemic on the prevalence of diabetic foot ulcers (DFUs) and the incidence of lower extremity amputation (LEA) in patients with type 2 diabetes.
methodsWe conducted a cross-sectional analysis using TriNetX and included adults with type 2 diabetes from 2016 to 2023. DFU prevalence and LEA incidence were analyzed across pre-pandemic, pandemic, and post-pandemic periods. Annual percent changes (APC) were calculated using Joinpoint regression.
resultsAmong 5,292,512 patients with type 2 diabetes (mean age, 66 ± 14.0 years; 47.3 % female), DFU prevalence increased pre-pandemic (APC 9.08%; 95% CI 6.24, 12.65), remained stable during the pandemic (APC -0.15%; 95% CI -1.94, 1.69), and rose significantly post-pandemic (APC 6.89%; 95% CI 3.50, 9.75). LEA incidence showed similar trends, which increased pre-pandemic (APC 9.18%; 95% CI 7.15, 12.58), remained stable during the pandemic (APC -3.75%; 95% CI -6.45, 0.63), and significantly increased post-pandemic (APC 11.46%; 95% CI 8.09, 19.63).
conclusionsThe disproportionately sharper increase in LEA rates compared with DFU prevalence post-pandemic suggests that delayed care during the pandemic may have contributed to a higher burden of preventable amputations.
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