Observational studyCardiovascular diabetology2026

Reamputation risk and mortality after lower-limb amputation in patients with diabetes: predictors, effects of antidiabetic medications and temporal trends.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

−41%−57% to −19%

Bigger than 8 in 10 for cardiovascular events

As reported

HR 0.59, 95% CI 0.43–0.81

Correlation, not cause

2×1.5× to 2.7×

Bigger than 9 in 10 for cardiovascular events

As reported

HR 2, 95% CI 1.47–2.72

the abstract, start to end

… risk of reamputation and mortality (HR 0.59, 95% CI [0.43, 0.81] …

While overall sodium-glucose transporter 2 inhibitor (SGLT2i) usage was …

← favours treatmentfavours comparator →

could be chance

Cardiovascular events

HR 0.590.43–0.81

Cardiovascular events

HR 21.47–2.72

MetforminSGLT2 inhibitorsCardiovascular events

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