Evidence map›Paper›PMID 40430019›Full record

ArticleInternational journal of molecular sciences2025

Characterization of Gut Microbiome Composition in Depression and Completed Suicide.

Samat Kozhakhmetov, Alibek Kossumov, Tolkyn Zhakupova, Tatyana Polyakova, Nazgul Imambayeva, Bagyzhan Syzdykova, Aidana Rakhmankulova, Gulshat Dalibayeva, Artur Kovenskiy, Zharkyn Jarmukhanov and 3 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samat KozhakhmetovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0001-9668-0327
Alibek KossumovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0001-7827-6697
Tolkyn ZhakupovaDepartment of Forensic Medicine, NJSC, Astana Medical University, Astana Z01G6C5, Kazakhstan.ORCID 0000-0002-5352-2895
Tatyana PolyakovaDepartment of Forensic Medicine, NJSC, Astana Medical University, Astana Z01G6C5, Kazakhstan.
Nazgul ImambayevaResearch Institute of Forensic Examinations of the State Enterprise, Center for Forensic Examinations of the Ministry of Justice of the Republic of Kazakhstan, Astana Z00X8P9, Kazakhstan.ORCID 0000-0003-3110-5406
Bagyzhan SyzdykovaDepartment of Forensic Medicine, NJSC, Astana Medical University, Astana Z01G6C5, Kazakhstan.ORCID 0000-0001-6540-7950
Aidana RakhmankulovaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0009-0001-3119-0738
Gulshat DalibayevaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.
Artur KovenskiyLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0009-0001-5608-2469
Zharkyn JarmukhanovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.
Argul IssilbayevaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0002-7350-6083
Elizaveta VinogradovaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0009-0003-1845-2726
Almagul KushugulovaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, 53 Kabanbay Batyr Ave., Block S1, Astana Z05H0P9, Kazakhstan.ORCID 0000-0001-9479-0899

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan AP19676162
6 · The paper itself

Abstract

Growing evidence supports a bidirectional relationship between the gut microbiome and mental health. This study investigated the association between gut microbiota, depression, and suicidal behavior by analyzing fecal samples from 35 individuals with varying depression levels and 36 completed suicide cases. Standardized psychometric assessments were used for depression evaluation. Analysis revealed significant taxonomic differences between groups, with increased abundance of

Indexed as

DepressionGastrointestinal MicrobiomeSuicide, CompletedAdultDysbiosisEnergy MetabolismFecesFemaleHumansMaleMiddle Ageddepressionenergy metabolismFirmicutesgut–brain axisgut microbiomeinflammationLachnospiraceaemental healthmetabolic pathwayssuicide

Identifiers

PMID40430019
PMCPMC12112742

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.