Dietary 5-Aminolevulinic Acid Alleviates Heat Stress-Induced Renal Injury in Laying Hens by Improving Mitochondrial Quality and Enhancing Antioxidant Activity.

Fumika Nanto-Hara, Haruhiko Ohtsu

Abstract read

In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Fumika Nanto-HaraDivision of Meat Animal and Poultry Research, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NILGS), Tsukuba 305-0901, Japan.

Haruhiko OhtsuDepartment of Research Promotion, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NILGS), Tsukuba 305-0901, Japan.

Funding

Environment Research and Technology Development Fund JPMEERF20S11820Japan Society for the Promotion of Science KAKENHI JP21K14966

6 · The paper itself

Abstract

This study aimed to evaluate the effects of dietary 5-aminolevulinic acid (ALA) on laying hens to alleviate chronic heat stress-induced renal damage, resulting in improved egg productivity and eggshell quality. A total of 57 white-leghorn laying hens (46 weeks old) were randomly assigned to three groups and fed three experimental diets with different levels of ALA (0, 10, and 100 ppm) for 1 week. The birds in each group were then divided into two subgroups; one of the two subgroups was subjected to heat stress (33 °C for 3 weeks), whereas the other group was maintained at 24 °C. Heat exposure significantly decreased the laying rate and eggshell strength and caused renal damage, whereas ALA supplementation alleviated heat-induced poor productivity and renal damage. ALA increased the renal mitochondrial DNA copy number and downregulated the expression of the cGAS-STING pathway-related genes in the kidneys of heat-stressed hens. Furthermore, ALA upregulated the renal expression levels of

Indexed as

5-aminolevulinic acidcGAS-STINGheat stressheme oxygenase-1laying hensmitochondriarenal damage

Identifiers

PMID40427438

DOI10.3390/antiox14050556

PMCPMC12108323

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